Sökning: "glycan recognition"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden glycan recognition.

  1. 1. Moleculary imprinted micro- and nanoparticles for cancer associated glycan motifs

    Författare :Liliia Mavliutova; Börje Sellergren; Michael Whitcombe; Malmö universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Moleculary imprinted polymer; sialic acid; glycan recognition; synthetic receptor;

    Sammanfattning : Sialic acids are an important family of monosaccharides that are typically found as terminal moieties of glycans. Aberrant sialylation has been proven to correlate with various diseases including cancer. Glycosylation analysis is complex due to high diversityof the glycan isomers and their low abundance. LÄS MER

  3. 2. Reading a glycocode - mechanism and function of galectin-glycan interactions

    Författare :Emma Salomonsson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; galectin; specificity; affinity; multivalency; fluorescence anisotropy; glycan array; serum glycoproteins; anginex;

    Sammanfattning : There is an intensive interest in characterising the structure and function of galectins, which is not surprising given their many important cellular functions and strong implications in human disease. Understanding the mechanisms involved in galectin functions will help to find selective and novel strategies for disease treatment and diagnosis. LÄS MER

  4. 3. Glycan-based interactions of Streptococcus pneumoniae and the host

    Författare :Karina Hentrich; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Streptococcus pneumoniae is commonly found as an asymptomatic colonizer of the nasopharynx of children, but it can also translocate to normally sterile body sites and cause severe diseases, like pneumonia, septicemia or meningitis. Pneumococci spread via aerosols. LÄS MER

  5. 4. Photochemical Ligation Techniques for Carbohydrate Biosensors and Protein Interaction Studies

    Författare :Oscar Norberg; Olof Ramström; Stéphane Vincent; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Carbohydrates; Biosensors; CuAAC; Photochemistry; Thiol-ene yne; Perfluorophenylazide PFPA ; Lectins; Molecular recognition; Quartz crystal microbalance QCM ; Surface plasmon resonance SPR ;

    Sammanfattning : This thesis concerns the development of surface ligation techniques for the preparation of carbohydrate biosensors. Several methodologies were developed based on efficient photochemical insertion reactions which quickly functionalize polymeric materials, with either carbohydrates or functional groups such as alkynes or alkenes. LÄS MER

  7. 5. Stimuli-responsive lipid bilayer mimics for protein, virus and cell recognition

    Författare :Sing Yee Yeung; Malmö universitet; []
    Nyckelord :Lipid bilayers; Adaptable; Self-assembled; Monolayers; Supramolecular chemistry; Cell adhesion; Biocensor;

    Sammanfattning : The most well-studied two-dimensional biomimetic cellular membrane modelsare self-assembled monolayers (SAMs) and supported lipid bilayers (SLBs).The former has the advantage of control over ligand density, homogeneity andorientation, allowing unambiguous interaction studies. LÄS MER