Sökning: "synthetic receptor"

Visar resultat 1 - 5 av 128 avhandlingar innehållade orden synthetic receptor.

1. 1. Peptide Receptor Radionuclide Therapy in Neuroendocrine Neoplasms : Aspects of tumour characteristics, receptor recycling and peptide mass

   Författare :Ulrika Jahn; Anders Sundin; Mark Lubberink; Ulrike Garske-Román; Mona-Elisabeth Rootwelt-Revheim; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroendocrine tumors; Peptide receptor radionuclide therapy PRRT ; Peptide; Small-Intestinal; Pancreatic; Dosimetry; Somatostatin receptor;

   Sammanfattning : Neuroendocrine neoplasm (NEN) can arise in any part of the body, but most commonly in the lungs, bronchi, and the gastrointestinal tract including the pancreas. They combine neuroendocrine and tissue-of-origin-specific characteristics; explaining different symptoms depending on the organ of origin. LÄS MER

3. 2. The estrogen receptor in fish and effects of synthetic estrogens in the environment - Ecological and evolutionary perspectives and societal awareness

   Författare :Lina Nikoleris; Biodiversitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; the estrogen receptor; salmon evolution and ecology; contraceptives; information gaps; synthetic hormones; EE2; Atlantic salmon Salmo salar ; brown trout Salmo trutta ; roach Rutilus rutilus ;

   Sammanfattning : Synthetic hormones are a group of pharmaceuticals used for various human and animal treatments. However, consumption and disposal of these substances have also given rise to negative effects and environmental problems for organisms in the wild which is why these substances have been classified as estrogenic endocrine-disrupting chemicals (EDCs). LÄS MER

4. 3. TRÖGER´S BASE AS SCAFFOLD FOR SYNTHETIC RECEPTORS

   Författare :Carlos Solano; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; Organisk kemi; Organic chemistry; Makromolekylär kemi; Macromolecular chemistry; Molecular Recognition; Tröger´s base; Synthetic Receptors; Fysikalisk kemi;

   Sammanfattning : This work focuses on the use of the Tröger´s base as organic scaffold for the construction of synthetic receptors for different classes of organic molecules. The structural properties of the Tröger's base, i.e. chirality, rigidity and curvature, allow for synthetic modifications towards the recognition of different molecules. LÄS MER

5. 4. Design, Synthesis and Biological Evaluation of Selective Nonpeptide AT2 Receptor Agonists and Antagonists

   Författare :Charlotta Wallinder; Anders Hallberg; Mathias Alterman; Anders Karlén; Elizabeth E. Sugg; Uppsala universitet; []
   Nyckelord :AT2 receptor agonist; AT2 receptor antagonist; Ang II peptidomimetics;

   Sammanfattning : The G protein-coupled receptors (GPCRs) are important targets in drug discovery. In several cases, the endogenous ligands that activate the GPCRs of pharmaceutical interest are peptides. LÄS MER

7. 5. Molecular basis of estrogen receptor antagonism

   Författare :Nina Heldring; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Estrogen Receptor; antagonism; receptor signaling; phytoestrogen and conformational changes;

   Sammanfattning : Estrogen Receptors (ERs), ERα and ERβ, are responsible for mediating the physiological effects of the steroid hormone 17b-estradiol and structurally related compounds. ER signaling is a complex process where the combined effects of accessory proteins, known as coregulators, promoter characteristics and influence from other signaling systems, determine the cell-specific transcriptional response in a given situation. LÄS MER