Sökning: "glucotoxicity"
Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet glucotoxicity.
1. Glucotoxicity in Insulin-Producing β-Cells
Sammanfattning : Background and aims: Type 2 diabetes mellitus is connected with elevated glucose levels, which cause impaired glucose-stimulated insulin secretion (GSIS) and degeneration of β-cells. Mechanisms for such glucotoxic effects were explored in the present study.Materials and methods: INS-1E cells were cultured for 5 days in 5. LÄS MER
2. Mechanisms underlying lipotoxicity and glucotoxicity in pancreatic islets
Sammanfattning : Although it has been known for many years that long-term exposure of pancreatic islets to a high level of free fatty acids (FFA) or glucose negatively modulates islet hormone release, the identities of signals mediating these effects are not yet fully clarified. The overall objective of this study was to investigate signal transduction pathways involved in FFA- and glucose-exerted effects on beta-cell function during both short-term as well as long-term exposure. LÄS MER
3. The impact of glucotoxicity on pancreatic β-cell function
Sammanfattning : Type 2 diabetes mellitus is connected with elevated plasma glucose levels which negatively influence β-cells and cause impaired glucose-stimulated insulin secretion (GSIS). The aim of present thesis was to investigate the impact of long-term hyperglycemia on the pancreatic islet β-cell function. LÄS MER
4. A MATTER OF NUTRIENT EXCESS AND SHEAR STRESS
Sammanfattning : The metabolic syndrome is a clustering of several risk factors associated with diabetes and cardiovascular disease. Diabetes is a global problem with 90% of patients suffering from type 2 diabetes (T2D), which is attributable to various factors including genetic predispositions and lifestyle. LÄS MER
5. Effects of Total Parenteral Nutrition on the Exocrine and Endocrine Pancreas. An Experimental Study
Sammanfattning : During total parenteral nutrition (TPN) adequate nutrition is provided intravenously and the enteral route is bypassed. The integrity of the gastrointestinal (GI) tract, however, is dependent on the passage of food through it. This thesis deals with the effects of TPN on the pancreas and the parotid glands. LÄS MER