Sökning: "Sandra Meidute"

Hittade 1 avhandling innehållade orden Sandra Meidute.

1. 1. Mechanisms underlying lipotoxicity and glucotoxicity in pancreatic islets

   Författare :Sandra Meidute; Islet cell physiology; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hormone secretion; cell stress; Pancreatic beta-cell; cellular signalling; GPR40; diabetes;

   Sammanfattning : Although it has been known for many years that long-term exposure of pancreatic islets to a high level of free fatty acids (FFA) or glucose negatively modulates islet hormone release, the identities of signals mediating these effects are not yet fully clarified. The overall objective of this study was to investigate signal transduction pathways involved in FFA- and glucose-exerted effects on beta-cell function during both short-term as well as long-term exposure. LÄS MER