Sökning: "gene duplication"

Visar resultat 6 - 10 av 112 avhandlingar innehållade orden gene duplication.

1. 6. Variation in length of proteins by repeats and disorder regions

   Författare :Rauan Sagit; Arne Elofsson; Andrey Kajava; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein length; repeats; domain repeats; protein evolution; duplication; tandem duplication; intrinsic disorder; intrinsically disordered; variation in length; insertion; deletion; recombination; expansion; contraction; Biochemistry; biokemi;

   Sammanfattning : Protein-coding genes evolve together with their genome and acquire changes, some of which affect the length of their protein products. This explains why equivalent proteins from different species can exhibit length differences. LÄS MER

3. 7. Evolutionary Genomics of Nematode-Trapping Fungi

   Författare :Tejashwari Meerupati; MEMEG; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nematode-trapping fungi; Comparative Genomics; Comparative Transcriptomics; Differential gene expression; Gene duplication; Parasitism; Protein family expansion.;

   Sammanfattning : Nematode-trapping fungi are ubiquitous, soil-living organisms with the ability to infect and kill nematodes. These fungi have developed specialized infection structures for the capture of nematodes. LÄS MER

4. 8. Evolution of mate signalling in moths: Biosynthetic gene families and diversification of female sex pheromones

   Författare :Marjorie Liénard; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; duplication; transcriptome; fatty-acyl-CoA reductase; fatty-acyl-CoA desaturase; fatty-acid biosynthesis; odour; insect; Lepidoptera; phylogeny; qPCR; heterologous expression; mutagenesis;

   Sammanfattning : Pheromones are intraspecific chemical signals serving as a ubiquitous form of communication, particularly among insects. Female sex-pheromone signals act as the core constituent in the specialized odour-mediated moth mate-recognition system. Female moths typically release multicomponent mixtures of alcohols, aldehydes or acetates. LÄS MER

5. 9. The Human Y chromosome and its role in the developing male nervous system

   Författare :Martin M. Johansson; David Skuse; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MSY; sex differences; CNV; SNP; palindrome; palindromes; gr gr duplication; gr gr deletion; b2 b3 deletion; b2 b3 duplication; blue-grey duplication; blue-grey like duplication; IR2; U3; STS; AZFa; AZFb; AZFc; Olivary nucleus; Medulla oblongata; spinal cord; white matter; Affymetrix 6.0; embryo; embryonal; haplogroup; haplogroups; R1a; R1b; R-M207; E-M96; I-M170; J-M304; G-M201; Ashkenazi; Bolivian; Chinese; SNP array; padlock probing; AMY-tree; Biologi med inriktning mot zoologisk utvecklingsbiologi; Biology with specialization in Animal Development;

   Sammanfattning : Recent research demonstrated that besides a role in sex determination and male fertility, the Y chromosome is involved in additional functions including prostate cancer, sex-specific effects on the brain and behaviour, graft-versus-host disease, nociception, aggression and autoimmune diseases. The results presented in this thesis include an analysis of sex-biased genes encoded on the X and Y chromosomes of rodents. LÄS MER

7. 10. Pharmacokinetic consequences of CYP2D6 genotypes with emphasis on gene duplication / amplification

   Författare :Per Dalén; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Drug metabolism; CYP2D6. debrisoquine; nortriptyline; quinidine; genotype; phenotype; cytochrome P450; gene duplication; gene amplification;

   Sammanfattning : The relationship between the major Caucasian and Oriental CYP2D6 genotypes and the disposition of two CYP2D6 substrates nortriptyline and debrisoquine was investigated. Caucasians with 0, 1, 2, 3/4 and 13 functional CYP2D6-genes as well as Chinese and Korean subjects homo- and heterozygous for the CYP2D6*1 and CYP2D6*10 alleles were included. LÄS MER