Sökning: "quinidine"

Hittade 4 avhandlingar innehållade ordet quinidine.

  1. 1. Pharmacokinetic consequences of CYP2D6 genotypes with emphasis on gene duplication / amplification

    Författare :Per Dalén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Drug metabolism; CYP2D6. debrisoquine; nortriptyline; quinidine; genotype; phenotype; cytochrome P450; gene duplication; gene amplification;

    Sammanfattning : The relationship between the major Caucasian and Oriental CYP2D6 genotypes and the disposition of two CYP2D6 substrates nortriptyline and debrisoquine was investigated. Caucasians with 0, 1, 2, 3/4 and 13 functional CYP2D6-genes as well as Chinese and Korean subjects homo- and heterozygous for the CYP2D6*1 and CYP2D6*10 alleles were included. LÄS MER

  3. 2. Eco-friendly and Catalytic Surface Engineering of Cellulose and Nanocellulose

    Författare :Rana Alimohammadzadeh; Armando Cordova; Dan Bylund; Monica Ek; Mittuniversitetet; []
    Nyckelord :;

    Sammanfattning : The non-stop use of petroleum-based materials such as plastics can generate significant environmental problems, including pollution of the oceans and increased CO2 levels, and cause diseases like cancer due to the starting monomers. Consequently, increased use of sustainable and non-toxic polymers and monomers is required to address these issues. LÄS MER

  4. 3. Distribution of antiviral nucleoside analogues into brain and skin

    Författare :Natalia Borg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aim of this thesis was to study physiological and physico-chemical factors influencing the pharmacokinetics and distribution over the blood-brain barrier of antiviral nucleoside analogues in the rat, and to study the distribution to the human skin in vivo of an anti-herpetic nucleoside analogue. Microdialysis was used to sample the free (unbound) extracellular concentration of the nucleoside analogues from the brain tissue, muscle and blood in the rat and from the dermis of healthy human volunteers. LÄS MER

  5. 4. K+ channels and the regulation of synaptic transmission

    Författare :Evanthia Nanou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuronal excitability is highly regulated by K+ channels that are activated by a voltage change across the plasma membrane or by a rise in intracellular Na+ or Ca2+ concentration. The main focus of this thesis has been to characterize the Na+-activated K+ (KNa) and the Ca2+-activated K+ (KCa) channels and to determine their role in regulating synaptic transmission in the lamprey spinal cord. LÄS MER