Sökning: "gene discovery"
Visar resultat 1 - 5 av 234 avhandlingar innehållade orden gene discovery.
1. Animal genomics – gene discovery and gene characterization
Sammanfattning : This thesis involves two projects. The aim in the first project was to identify genomic regions associated with spontaneous autoimmune thyroiditis (SAT), which is a hereditary autoimmune disease that affects the obese strain (OS) of chicken, an animal model for human Hashimoto’s thyroiditis (HT). LÄS MER
2. Drug discovery against leishmaniasis : Bio- and chemoinformatic guided strategies for target evaluation and hit identification
Sammanfattning : Leishmaniasis is a neglected tropical disease mainly affecting poor people in developing countries. It is caused by infections of flagellated protozoa belonging to genus Leishmania. The few available drugs are associated with problems such as low effectiveness, severe side effects and resistance development. LÄS MER
3. A Genetic Survey of the Pathogenic Parasite Trypanosoma cruzi
Sammanfattning : Trypanosoma cruzi, the causative agent of Chagas´ disease, is an evolutionarily ancient species with distinct biological and immunological characteristics. A fundamental understanding of the basic biology of the parasite is necessary in order to develop reliable therapeutic and prophylactic agents against T. cruzi. We have, as a part of the T. LÄS MER
4. Embracing the data flood : integrating diverse data to improve phenotype association discovery in forest trees
Sammanfattning : Complex traits represent valuable research targets as many highly desirable properties of plants and animals (such as growth rate and height) fall into this group. However, associating biological markers with these traits is incredibly challenging, in part due to their small effect sizes. LÄS MER
5. Sex pheromone biosynthesis in moth pests : From gene discovery to biotechnological production
Sammanfattning : Moths (Lepidoptera) are some of the most economically important pests in human agriculture. Conventional insecticides used for management promote insecticide resistance in addition to cause human- and environmental harm. This emphasises an inescapable need for sustainable alternatives and integrated practices. LÄS MER