Sökning: "Association Discovery"

Visar resultat 1 - 5 av 78 avhandlingar innehållade orden Association Discovery.

1. 1. Embracing the data flood : integrating diverse data to improve phenotype association discovery in forest trees

   Författare :Bastian Schiffthaler; Nathaniel Street; Martin Rosvall; Nicolas Delhomme; Marek Mutwil; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Systems Biology; Association Discovery; Genomics; Transcriptomics; Genome Assembly; Gene Networks; Forest Tree; Aspen; Spruce; biology; biologi;

   Sammanfattning : Complex traits represent valuable research targets as many highly desirable properties of plants and animals (such as growth rate and height) fall into this group. However, associating biological markers with these traits is incredibly challenging, in part due to their small effect sizes. LÄS MER

3. 2. Living with VACTERL association : From the perspectives of children, adolescents and their parents

   Författare :Ann-Marie Kassa; Helene Engstrand Lilja; Gunn Engvall; Agneta Anderzén Carlsson; Uppsala universitet; []
   Nyckelord :Congenital malformations; Experiences of health care; Health-related quality of life; Neurodevelopmental function; Physical dysfunction; Psychological well-being; VACTERL association; Barnkirurgi; Pediatric Surgery;

   Sammanfattning : VACTERL association is a rare and complex congenital condition often requiring repeated surgery and entailing various physical sequelae. Knowledge is scarce regarding experiences of the health condition and health care, need of support at school, health-related quality of life (HRQoL), and psychological well-being in children, adolescents and their parents. LÄS MER

4. 3. Interaction Studies of Secreted Aspartic Proteases (Saps) from Candida albicans : Application for Drug Discovery

   Författare :Dan Backman; Helena Danielson; Birgitta Tomkinson; Gunnar Henriksson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; SPR Biosensor; Secreted aspartic proteases; Candida albicans; interaction kinetics; drug discovery; protease inhibitor; Biokemi; Biochemistry; Biokemi;

   Sammanfattning : This thesis is focused on enzymatic studies of the secreted aspartic proteases (Saps) from Candida albicans as a tool for discovery of anti-candida drugs. C. albicans causes infections in a number of different locations, which differ widely in the protein substrates available and pH. Since C. LÄS MER

5. 4. Protease Activity, Inhibition and Ligand Interaction Analysis : Developments and Applications for Drug Discovery

   Författare :Thomas Gossas; Helena Danielson; Mikael Widersten; Alexander Wlodawer; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; proteases; kinetics; biosensors; inhibition; calcium; drug discovery; Biokemi;

   Sammanfattning : The present study has focused on characterising protease-ligand interactions in the context of drug discovery. The proteases that have been studied are human matrix metallopeptidase 12 (MMP-12), HIV-protease and Hepatitis C virus (HCV) NS3/NS4A protease. LÄS MER

7. 5. Analysis of the interaction between HIV-1 protease and inhibitors : Applications for drug discovery

   Författare :Per-Olof Markgren; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; Biokemi; Biochemistry;

   Sammanfattning : The aims of this study were to identify and characterize inhibitors of HIV-l protease aspotential leads in a drug discovery process, and to develop improved methods for suchcharacterization. More than 300 inhibitors, including linear and cyclic peptidomimetictransition state analogs and Cu2+, were analyzed. LÄS MER