Sökning: "CL Brener"

Hittade 4 avhandlingar innehållade orden CL Brener.

  1. 1. A Genetic Survey of the Pathogenic Parasite Trypanosoma cruzi

    Författare :Anh-Nhi Tran; Lena Åslund; John Kelly; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Trypanosoma cruzi; Chagas ; gene discovery; EST; sequencing; DGC3; repeats; gene family; CL Brener; trypanothione synthetase; TcTRS locus; alleles; polymorphism; RNA-binding protein; TcPTB; stage-specific expression; Genetik; Genetics; Genetik; medicinsk genetik; Medical Genetics;

    Sammanfattning : Trypanosoma cruzi, the causative agent of Chagas´ disease, is an evolutionarily ancient species with distinct biological and immunological characteristics. A fundamental understanding of the basic biology of the parasite is necessary in order to develop reliable therapeutic and prophylactic agents against T. cruzi. We have, as a part of the T. LÄS MER

  3. 2. Mapping the genome and characterization of an acetyltransferase of Trypanosoma cruzi

    Författare :Stephen O Ochaya; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Trypanosoma cruzi; Chagas´disease; karyotyping; genomic; acetyltransferase;

    Sammanfattning : Trypanosoma cruzi (T.cruzi) is a flagellate protozoan parasite that causes Chagas' disease and is most common in Latin American countries. The disease currently infects over 13 million persons and about 100 million more are at risk. Despite basic research for many years, there is neither a vaccine nor useful drugs available to combat the disease. LÄS MER

  4. 3. Genome characterisation and mobility investigation in trypanosomes

    Författare :Carole Branche; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Trypanosoma brucei - Trypanosoma cruzi - karyotype - genome organisation -flageflum mobility - RNAi - functional studies.;

    Sammanfattning : Trypanosomes are uni-flagellated protozoa responsible for some of the most debilitating human infections such as Chagas disease (Trypanosoma cruzi) and sleeping sickness (Trypanosoma brucei). Unravelling their genome organisation and their biology would improve our basic knowledge and could contribute to find new drug target specific to the species. LÄS MER

  5. 4. Comparative genomics and molecular characterization of N-alpha acetyltransferase in trypanosomes for drug target identification

    Författare :Stephen Ochaya; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Trypanosoma cruzi and Trypanosoma brucei are flagellated protozoan parasites that cause Chagas disease and African trypanosomiasis in Latin American and African countries, respectively. Currently, over 8 million people are infected with T. cruzi and about 25 million more are at risk. About half a million people are affected by T. LÄS MER