Sökning: "Igf2"
Visar resultat 1 - 5 av 39 avhandlingar innehållade ordet Igf2.
1. CTCF and Epigenetic Regulation of the H19/Igf2 Locus
Sammanfattning : An overall coordination between the expressions of genes is required for the proper development of an individual. Although most genes are expressed from both the constituent alleles of the genome, a small subset of autosomal genes are preferentially expressed from only one of the parental alleles, a phenomenon known as genomic imprinting. LÄS MER
2. Functional characterization of the biological significance of the ZBED6/ZC3H11A locus in placental mammals
Sammanfattning : The recent advances in molecular and computational biology have made possible the study of complicated transcriptional regulatory networks that control a wide range of biological processes and phenotypic traits. In this thesis, several approaches were combined including next generation sequencing, gene expression profiling, chromatin and RNA immunoprecipitation, bioinformatics and genome editing methods in order to characterize the biological significance of the ZBED6 and ZC3H11A genes. LÄS MER
3. Animal genomics – gene discovery and gene characterization
Sammanfattning : This thesis involves two projects. The aim in the first project was to identify genomic regions associated with spontaneous autoimmune thyroiditis (SAT), which is a hereditary autoimmune disease that affects the obese strain (OS) of chicken, an animal model for human Hashimoto’s thyroiditis (HT). LÄS MER
4. Functional Studies of Genes Associated with Muscle Growth in Pigs and Hair Greying in Horses
Sammanfattning : Domestic animals have become very different from their wild ancestors during domestication and animal breeding. This provides a good model to unravel the molecular mechanisms underlying phenotypic variation. In my thesis I have studied genes affecting two important traits, leanness in pigs and hair greying-associated melanoma in horses. LÄS MER
5. Epigenetic Regulation and Reprogramming of the H19 Imprinting Control Region
Sammanfattning : The development of a new individual from the fertilized oocyte can ultimately be seen as the consequence of the establishment and maintenance of specific patterns of gene expression. Although regulation of gene activity occurs at different levels, cellular specialization and differentiation are the results of developmental cues that essentially take place at the transcriptional level. LÄS MER