Sökning: "extracellular nucleotides"

Visar resultat 1 - 5 av 20 avhandlingar innehållade orden extracellular nucleotides.

  1. 1. Oxidized nucleotides as a predictor of radiation sensitivity

    Författare :Ali Pour Khavari; Siamak Haghdoost; Marie Öhman; Anders Nilsson; Bo Stenerlöw; Neus Visa; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; 8-oxo-dG; Radiation; Sensitivity; Oxidized; Nucleotides; ROS; NOS; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : The direct and indirect effects of IR can lead to DNA damage and activation of DNA repair. The indirect effects of ionizing radiation mediated by reactive oxygen species (ROS) which produced through radiolysis of water and if not taken care of by the antioxidant system, can also give rise to oxidative stress. LÄS MER

  3. 2. Local regulation of the endogenous fibrinolytic system in man

    Författare :Thordis Hrafnkelsdottir; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tissue-type plasminogen activator; plasminogen activator inhibitor type-1; endothelium; extracellular nucleotides; hypertension; chronic renal failure;

    Sammanfattning : The physiologically most important activator of intravascular fibrinolysis is tissue-type plasminogen activator (tPA). The endothelium synthesises and stores tPA and regulated release of the enzyme is an important mechanism for removal of fibrin from blood vessels. Plasminogen activator inhibitor type-1 (PAI-1) is the main inhibitor of tPA. LÄS MER

  4. 3. Endogenous antioxidants in human skeletal muscle and adaption in energy metabolism : with reference to exercise-training, exercise-related factors and nutrition

    Författare :Michael B Svensson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :GSH; urate; Q10; Ubiquinone-10; myoblasts; muscle stem cells; high-intensity exercise; performance; overload training; adenine nucleotides; AMP deaminase; glycogen; carbohydrates.;

    Sammanfattning : The antioxidant homeostasis is determined by a wide array of interacting cellular antioxidants, as well as being influenced by the homeostasis in energy metabolism. Changes in antioxidant homeostasis, as a consequences of altered production of reactive oxygen species (ROS). and/or by changes in the resident levels of antioxidants. LÄS MER

  5. 4. Studies of nucleotide receptors-induced calcium response in glomerular mesangial cells and afferent arterioles

    Författare :Antonio M. Gutiérrez; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; mesangial cells; nucleotide receptors; purinoceptors; desensitization; afferent arterioles; ATP; UTP; adenosine; protein phosphatases; calcium; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

    Sammanfattning : It is known that intracellular calcium concentration ([Ca2+]i) changes in rat glomerular mesangial cells (GMC) and rabbit afferent arterioles (AA) in response to extracellular nucleotides. We studied the nucleotide-induced calcium response in cultured GMC and AA. LÄS MER

  7. 5. The role of MTH1 in ultraviolet radiation-induced mutagenesis

    Författare :Asal Fotouhi; Siamak Haghdoost; Harry Vrieling; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ultraviolet radiation; MTH1; reactive oxygen species; 8-oxo-dGTP; 2-OH-dATP; micronucleus; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Ultraviolet radiation (UVR) is known to be highly mutagenic. What types of DNA lesions that are induced by different UVR wavelengths are still a matter of debate. UVR induces mutagenesis mostly by the formation of photoproducts and the induction of reactive oxygen species (ROS). LÄS MER