Sökning: "micronucleus"
Hittade 5 avhandlingar innehållade ordet micronucleus.
1. The role of MTH1 in ultraviolet radiation-induced mutagenesis
Sammanfattning : Ultraviolet radiation (UVR) is known to be highly mutagenic. What types of DNA lesions that are induced by different UVR wavelengths are still a matter of debate. UVR induces mutagenesis mostly by the formation of photoproducts and the induction of reactive oxygen species (ROS). LÄS MER
2. The effect on chromosomal stability of some dietary constituents
Sammanfattning : When food is heated, a vast number of compounds are formed. Some of these are known to be toxic. Among these are furan, HMF, PhIP, IQ, and MeIQx, the subjects of this thesis. All these compounds are known or suspected carcinogens but the detailed mechanisms behind their carcinogenicity have not yet been fully examined. LÄS MER
3. Chromosome aberrations detected by the flow cytometer based micronucleus assay : studies of rodent erythrocytes after exposure to very low doses of ionizing radiation or to chemicals
Sammanfattning : .... LÄS MER
4. Occurrence and ecotoxicity of endocrine disruptor chemicals in aquatic environment and sewage treatment systems
Sammanfattning : The applicability of one selected method for indirect measurement of vitellogenin (Vtg) in fish plasma based on the quantification of alkali-labile phosphates (ALP method) to assess estrogenicity in water was investigated. The ALP method applied in this investigation was originally developed with Carassius carassius (Crucian carps). LÄS MER
5. Biomarkers of ionising radiation relevant to carcinogenesis : Dose, dose rate and LET dependency of the responses
Sammanfattning : A better understanding of the relationship between ionising radiation (IR) dose, dose rate and radiation quality, and the risk of stochastic effects would improve risk extrapolation from atomic bomb survivors’ data. Owing to insufficient statistical power of epidemiological studies to detect excess incidence of cancer following low doses of IR delivered at low dose rates (LDLDR), as typically encountered in most common human exposure scenarios, radiobiological experiments are fundamental to describe the biological effectiveness of LDLDR and to define the underlying molecular mechanisms. LÄS MER