Sökning: "endogenous peptides"

Visar resultat 16 - 20 av 101 avhandlingar innehållade orden endogenous peptides.

  1. 16. Expression of cathelicidin antimicrobial peptides in man and rat

    Författare :Stefan Termén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :LL-37; rCRAMP; butyrate; colonic epithelium; central nervous system; transcription;

    Sammanfattning : Endogenous antimicrobial peptides are effectors of innate immunity. They kill microorganisms by disrupting their cell membranes, but are also believed to have signaling functions in the immune system. They are present in epithelia, secretions and phagocytic cells. LÄS MER

  3. 17. Expression and regulation of antimicrobial peptides in mucosal immunity

    Författare :Andreas Cederlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Antimicrobial polypeptides (AMPs) are effector molecules of the innate immune defense. AMPs are mainly expressed in epithelial cells and immune cells, providing the first line of defense to infection as direct antimicrobials. In addition, many AMPs display immunomodulatory functions in both the adaptive and innate immune system. LÄS MER

  4. 18. Early Environment, Adolescent Alcohol Drinking and Neurobiological Responses to Drugs

    Författare :Sara Palm; Ingrid Nylander; Anne-Lie Svensson; Lundblad Martin; Giancarlo Colombo; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adolescence; beta-endorphin; dopamine; dynorphin; endogenous opioids; enkephalin; high-speed chronoamperometry; housing conditions; maternal separation; multivariate concentric square field™ test; open field test; radioimmunoassay; voluntary alcohol intake; Wistar rats; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : Genes and environment interact to determine an individual’s vulnerability or resilience to several psychiatric disorders, including alcohol use disorder (AUD). Alcohol use is often initiated during adolescence and early onset drinking is associated with increased risk for later AUD. LÄS MER

  5. 19. Anabolic Androgenic Steroids and the Brain : Studies of Neurochemical and Behavioural Changes Using an Animal Model

    Författare :Pia Steensland; Christina Gianoulakis; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Anabolic Androgenic Steroids AAS ; aggression; alcohol intake; defensive behaviours; dependence; opioid peptides; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; biologisk beroendeforskning; Biological Research on Drug Dependence;

    Sammanfattning : A new group of anabolic androgenic steroid (AAS) users has developed during the last two decades. This group consists primarily of young men interested in improving their physical appearance. Within this group, AAS are sometimes used together with other illicit drugs, alcohol and nicotine. LÄS MER

  7. 20. Novel host defence mechanisms during bacterial infections

    Författare :Malin Elvén; Lund Dermatologi och venereologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ApoE; Complement System; TFPI-2; Antimicrobial peptides; AMP; Immunolgobulins; endotoxins; Staphylococcus aureus; Pseudomonas aeruginosa; Escheria coli;

    Sammanfattning : The immune system has evolved through thousands of years and its architecture has challenged the medical field since the first hieroglyphs and will likely continue do so. With our co-evolution with millions of other species, the complexity to treat infectious diseases has been a race in increasing speed ever since. LÄS MER