Sökning: "thymidylate synthase"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden thymidylate synthase.

  1. 1. Optimisation of Chemotherapy Treatment in Advanced Colorectal Cancer

    Författare :Åke Berglund; Ragnar Hultborn; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Colorectal cancer; chemotherapy; 5-fluorouracil; dose-effect relationship; ex vivo assay; thymidylate synthase; p53; CEA; TPS; VEGF; bFGF.; Onkologi; Oncology; Onkologi; Oncology; onkologi;

    Sammanfattning : Colorectal cancer is one of the most common malignant diseases in Sweden – more than 5000 new cases are diagnosed each year. The overall five-year survival is about 60% and in cases of recurrence the prognosis is poor. LÄS MER

  3. 2. Thymidylate synthase expression and mismatch repair protein expression in colorectal cancer

    Författare :Katarina Öhrling; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The tumour, node, metastasis (TNM) system, with the current staging and risk stratification methods for prognostication in colorectal cancer (CRC) has its limitations. The need for additional validated prognostic and predictive markers is particularly important in CRC stage II and III as some of these patients can be cured by surgery alone. LÄS MER

  4. 3. Thymidylate synthase expression in colorectal cancer : its role as a prognostic factor and a predictive factor in adjuvant 5-fluorouracil-based chemotherapy

    Författare :David Edler; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Colorectal cancer; thymidylate synthase; immunohistochemistry; prognostic factor; 5-fluorouracil; adjuvant treatment;

    Sammanfattning : The enzyme thymidylate synthase (TS) plays a central role in DNA synthesis and is therefore an important target for chemotherapeutic treatment. We have studied the prognostic value of immunohistochemically detected TS on slices of formalin-fixed. paraffin embedded stored colorectal tumors using the monoclonal antibody TS 106. LÄS MER

  5. 4. Enzymes in thymidylate synthesis in Ureaplasma parvum as medical targets

    Författare :Jay Lin; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : The wall less bacterium Ureaplasma parvum (Up) is associated with ureathritis in adults and pneumonia in neonates. Up lack de novo nucleotide synthesis genes and has to import all DNA precursors. LÄS MER

  7. 5. Prognostic factors in colorectal cancer : studies of thymidylate synthase expression, mismatch repair protein expression, tumor budding and t-cell infiltration

    Författare :Mia Karlberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Colorectal cancer (CRC) is a major health problem in the Western world. CRC is treatable with surgery and often curable when the disease is diagnosed at an early stage. With improved surgery and adjuvant chemotherapy treatment, the disease-free-survival (DFS) rate for colon cancer is approximately 80% for stage II and for stage III close to 65%. LÄS MER