Sökning: "dose-effect relationship"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden dose-effect relationship.

  1. 1. Optimisation of Chemotherapy Treatment in Advanced Colorectal Cancer

    Författare :Åke Berglund; Ragnar Hultborn; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Colorectal cancer; chemotherapy; 5-fluorouracil; dose-effect relationship; ex vivo assay; thymidylate synthase; p53; CEA; TPS; VEGF; bFGF.; Onkologi; Oncology; Onkologi; Oncology; onkologi;

    Sammanfattning : Colorectal cancer is one of the most common malignant diseases in Sweden – more than 5000 new cases are diagnosed each year. The overall five-year survival is about 60% and in cases of recurrence the prognosis is poor. LÄS MER

  2. 2. Bone and kidney effects from cadmium exposure : dose effect and dose response relationships

    Författare :Tobias Alfvén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Bone; bone mineral density; cadmium; epidemiology; environmental exposure; fractures; heavy metals; human; kidneys; occupationally exposure; osteoporosis; protein HC; tubular proteinuria;

    Sammanfattning : Cadmium is a heavy metal that has been dispersed in the environment during the last century due to human activity. It is well known that high cadmium exposure causes renal damage and in severe cases also osteoporosis and osteomalacia. Osteoporosis is a major cause of morbidity worldwide. LÄS MER

  3. 3. The Importance of Dosimetry and Radiobiology in Nuclear Medicine : Quantitative methods and modelling

    Författare :Anna Stenvall; Lund Medicinsk strålningsfysik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nuclear medicine; radionuclide therapy; radiopharmaceutical therapy; dosimetry; Monte Carlo modelling; radiobiology; ; γH2AX; DOTA-TATE; PET; SPECT;

    Sammanfattning : Nuclear medicine uses radioactive pharmaceuticals for diagnostic or therapeutic purposes. The ionizing radiation emitted from the radiopharmaceutical is partially absorbed within the patient's body and internal dosimetry is the method to estimate the absorbed dose to a tumour or risk organ. LÄS MER

  4. 4. Malaria on islands : human and parasite diversities and implications for malaria control in Vanuatu

    Författare :Akira Kaneko; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :malaria; Plasmodium falciparum; Plasmodium vivax; glucose-6-phosphate dehydrogenase deficiency; CYP2C19; dihydrofolate reductase; cycloguanil; proguanil; mass drug administration; diversity; island; Vanuatu; Pacific;

    Sammanfattning : The genetic diversities displayed by human and malaria parasites at different frequencies in different geographical areas represent a major obstacle for the development of malaria control strategies including malaria chemotherapy and malaria vaccine. We investigated some genetic diversities on Vanuatu islands with various malaria endemicities. LÄS MER

  5. 5. Juvenile myoclonic epilepsy : clinical, genetic, clinical pharmacological, and neurophysiological studies

    Författare :Anders Sundqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :epilepsy; juvenile myoclonic epilepsy; idiopathic generalised epilepsy; differential diagnosis; genetics; linkage; valproic acid; pharmacokinetics; treatment; drug monitoring; EEG; neurophysiology; neuropsychology. Printed in Sweden by Repro Print; ;

    Sammanfattning : Juvenile myoclonic epilepsy (JME) has been considered to be a discrete phenotype. Evidence from segregation analysis and twin studies suggest that JME is a genetically determined disease, and two previous linkage studies of separately ascertained kindreds have suggested that a JME locus, EJM 1, resides on chromosome 6p close to the HLA region. LÄS MER