Sökning: "discovery"

Visar resultat 11 - 15 av 1204 avhandlingar innehållade ordet discovery.

  1. 11. Geospatial Knowledge Discovery using Volunteered Geographic Information : a Complex System Perspective

    Författare :Tao Jia; Bin Jiang; Yifang Ban; Itzhak Benenson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; knowledge discovery; urban systems; complex system; VGI; OSM; GPS tracking dataset; scaling; heavy-tailed distribution detection; urban sprawl; Zipf’s law; human activity mobility patterns; agent-based modeling; complex network.;

    Sammanfattning : The continuous progression of urbanization has resulted in an increasing number of people living in cities or towns. In parallel, advancements in technologies, such as the Internet, telecommunications, and transportation, have allowed for better connectivity among people. LÄS MER

  2. 12. Exploring Inhibitors of HIV-1 Protease : Interaction Studies with Applications for Drug Discovery

    Författare :Maria T. Lindgren; Helena Danielson; Jozsef Tözser; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; kinetics; biosensors; ADME; drug discovery; SPR; resistance; inhibition; copper; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : A variety of HIV-1 protease inhibitors and their interactions with the enzyme have been characterized in order to identify novel and improved drugs against AIDS. The investigated inhibitors were represented by clinical and non-clinical inhibitors, active site and allosteric inhibitors, transition-state analogues and metal-ions. LÄS MER

  3. 13. Accelerating the discovery of drugs for Neglected Tropical Diseases using biophysical methods

    Författare :Giulia Opassi; Helena Danielson; Jenny Sandmark; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Neglected Tropical Diseases; Drug Discovery; Biochemistry; Biophysics; Kinetic; Fragment Based Lead Discovery; Assay Development;

    Sammanfattning : Even though they account for 10% of the global disease burden and besides the new record of funding in 2018, tropical diseases are still neglected by the majority of pharmaceutical companies and public funding. The reason can be mostly found in the fact that for these diseases a conventional drug discovery process is often too expensive. LÄS MER

  4. 14. New methods for phenotypic antibody discovery

    Författare :Jenny Mattsson; Hematogenomics; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Phenotypic antibody discovery; Therapeutic antibodies; Phage display; CRISPR Cas9;

    Sammanfattning : .... LÄS MER

  5. 15. Experimental Designs at the Crossroads of Drug Discovery

    Författare :Ing-Marie Olsson; Svante Wold; Johan Gottfries; Michael Sjöström; Bo Nordén; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; Design of experiments; Experimental design; Multivariate data-analysis; D-optimal design; 96-well technology; Drug discovery; Assay optimisation; QSAR; Organic chemistry; Organisk kemi;

    Sammanfattning : New techniques and approaches for organic synthesis, purification and biological testing are enabling pharmaceutical industries to produce and test increasing numbers of compounds every year. Surprisingly, this has not led to more new drugs reaching the market, prompting two questions – why is there not a better correlation between their efforts and output, and can it be improved? One possible way to make the drug discovery process more efficient is to ensure, at an early stage, that the tested compounds are diverse, representative and of high quality. LÄS MER