Sökning: "clonal heterogeneity"
Visar resultat 6 - 10 av 34 avhandlingar innehållade orden clonal heterogeneity.
6. Unwinding the layers of high hyperdiploid childhood acute lymphoblastic leukemia
Sammanfattning : .... LÄS MER
7. Charting the Genetic Landscape and Clonal Architectures of Pheochromocytoma
Sammanfattning : Genotypic and phenotypic inter patient heterogeneity characterize pheochromocytoma and paraganglioma (PPGL). Up to 60% of PPGL are associated with either somatic or germline mutations in at least 14 established disease causing genes. LÄS MER
8. Somatic Genetic Variation in Children: from Mosaicism to Cancer
Sammanfattning : This thesis concerns various aspects of somatic mosaicism and genetic intratumor heterogeneity in childhood cancer.In paper I, I show that aneuploidy in itself does not lead to the level of chromosomal instability that is typically seen in malignant cells. This finding strongly argues against the so called autocatalytic theory of carcinogenesis. LÄS MER
9. Molecular mechanisms involved in glioma cell interactions in vitro and studies of PDGF B transcript variants
Sammanfattning : Glioblastoma multiforme is a malignant brain tumor characterized by heterogeneity.Interactions between heterogeneous tumor cells are supposed to affect the behavior of awhole tumor cell population. LÄS MER
10. Sequencing cancer
Sammanfattning : Cancer forms highly heterogeneous tissues at several molecular levels, genomic, proteomic, transcriptomic and other epigenetic traits. The level of complexity is further augmented by the dynamic nature of tumor progression with cancer cell populations evolving in a clonal manner. LÄS MER