Sökning: "circular permutation."

Hittade 5 avhandlingar innehållade orden circular permutation..

  1. 1. Protein Folding Studies on the Ribosomal Protein S6: the Role of Entropy in Nucleation

    Författare :Magnus Lindberg; Mikael Oliveberg; Jane Clarke; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; protein folding; circular permutation; topology; connectivity; entropy; protein stability; chevron plot; Biokemi; Biochemistry; Biokemi; Biochemistry; biokemi;

    Sammanfattning : One of the most challenging tasks remaining in the field of biochemistry is the one of understanding how the information within the amino acid sequence of proteins translates into a unique structure. Solving this problem would lead to endless possibilities for application in the medical and biotechnology industry. LÄS MER

  3. 2. Crystallographic studies of transaldolase : implications for the enzymatic mechanism and the evolution of class I aldolases

    Författare :Jia Jia; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :transaldolase; aldolase; Schiff-base intermediate; protein crystallography; site directed mutagenesis; catalytic mechanism; circular permutation.;

    Sammanfattning : Transaldolase catalyzes the reversible transfer of a dihydroxyacetone moiety from a ketose donor to an aldose acceptor by forming a Schiff-base intermediate between a Iysine residue and dihydroxyacetone. It belongs to the class I aldolase family. LÄS MER

  4. 3. Folding of the Ribosomal protein S6 : The role of sequence connectivity, overlapping foldons, and parallel pathways

    Författare :Ellinor Haglund; Mikael Oliveberg; Neil Ferguson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein folding; protein stability; two-state folding; S6; chevron plot; transition state; parallell pathways; foldon; two-channel landscape; protein engineering; H D-exchange; Biochemistry; Biokemi; Biochemistry; biokemi;

    Sammanfattning : To investigate how protein folding is affected by sequence connectivity five topological variants of the ribosomal protein S6 were constructed through circular permutation.  In these constructs, the chain connectivity (i.e. the order of secondary-structure elements) is changed without changing the native-state topology. LÄS MER

  5. 4. Dynamics and limits in algebraic combinatorics

    Författare :Samu Potka; Svante Linusson; Victor Reiner; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mathematics; Matematik;

    Sammanfattning : This thesis consists of the following six articles.Properties of the Edelman-Greene bijection. Edelman and Greene constructed a correspondence between reduced words of the reverse permutation and standard Young tableaux. LÄS MER

  7. 5. Human Forkhead Genes

    Författare :Stefan Pierrou; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; transcription factor; FREAC; human forkhead homologues;

    Sammanfattning : The forkhead family constitutes a group of genes which encodes transcription factors that share a common DNA-binding domain, the forkhead domain. The first member to be discovered was the Drosophila melanogaster gene fork head. Members of this family have been found in a variety of species from bakers' yeast to man. LÄS MER