Sökning: "cdkn2A"
Visar resultat 11 - 15 av 52 avhandlingar innehållade ordet cdkn2A.
11. Role of the CDKN2A and related cell cycle regulatory genes in melanoma and other human cancers
Sammanfattning : The main objective of this thesis has been to investigate the involvement of the CDKN2A (p16INK4a and p14ARF) and related cell cycle regulatory genes in melanoma and other types of human cancer. The CDKN2A gene represents a unique locus in the entire human genome. LÄS MER
12. Molecular changes in the tumour suppressor genes p53 and CDKN2A/ARF in human urinary bladder cancer
Sammanfattning : Urinary bladder neoplasm is the ninth most common cancer in Europe and the United States. The incidence in Sweden is approximately 32 for men and 9 for women per 105 subjects and year and almost all cases are transitional cell carcinoma (TCC). LÄS MER
13. Further delineation of molecular alterations in adreno-medullary tumors
Sammanfattning : Pheochromocytomas, abdominal paragangliomas and neuroblastomas are tumors of the sympathetic nervous system. Anatomically pheochromocytomas and abdominal paragangliomas arise from sympathoadrenal paraganglia, within and outside the adrenal medulla, respectively. LÄS MER
14. Malignant melanoma in children and adolescents
Sammanfattning : The aim of the work reported in the present thesis was to investigate malignant melanoma in children and adolescents. Through epidemiological studies, we wished to investigate incidence, clinical factors and prognosis and to study the records. LÄS MER
15. Functional characterization of the alternative reading frame protein p14ARF
Sammanfattning : A deeper understanding of the molecular events underlying tumor development is a prerequisite for the design of novel and efficient therapies. Inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways appears as a common theme in most malignant human tumors. LÄS MER