Sökning: "carcinoid tumors"

Visar resultat 6 - 10 av 17 avhandlingar innehållade orden carcinoid tumors.

  1. 6. Genetic studies of endocrine abdominal tumors

    Författare :Ola Hessman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; MEN1; LOH; pancreatic endocrine tumors; midgut carcinoid; Smad4 DPC4; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Sammanfattning : Pancreatic endocrine tumors (PETs) occur sporadically or in the familial multiple endocrine neoplasia type 1 (MEN1) syndrome, whereas midgut carcinoids are nonfamilial, malignant endocrine tumors of the intestine. For these tumor entities morphological criteria are of limited use for prognostic prediction and selection of treatment. LÄS MER

  2. 7. Positron Emission Tomography in the Management of Neuroendocrine Tumors

    Författare :Håkan Örlefors; Barbro Eriksson; Mats Bergstrom; Anders Sundin; Karel Pacak; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Neuroendocrine tumor NET ; carcinoid; endocrine pancreatic tumor EPT ; Positron Emission Tomography PET ; serotonin-precursor; 5-hydroxytrytophan 5-HTP ; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Medicin; Medicine;

    Sammanfattning : Neuroendocrine tumors (NET´s) are often characterized by overproduction of peptide hormones. In spite of pronounced clinical symptoms, the tumor lesions can be small and difficult to detect. LÄS MER

  3. 8. Interferon-alpha signaling and cell cycle regulation in neuroendocrine tumors of the digestive system

    Författare :Yinghua Zhou; Uppsala universitet; []
    Nyckelord :Medical sciences; interferon-α; carcinoid tumors; interferon regulatory factor; p68; PKR; p21; p27; cell cycle; cyclin-dependent kinase; protein phosphorylation; protein trafficking; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : The prognosis for untreated carcinoid patients is poor and their quality of life is low. IFN-α treatment has shown a response rate of 50-80%, however, the antitumor mechanism has not been elucidated. LÄS MER

  4. 9. Oncolytic Adenovirus Therapy of Neuroendocrine Tumors

    Författare :Justyna Leja; Magnus Essand; Valeria Giandomenico; Akseli Hemminki; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adenovirus; virotherapy; oncolytic virus; neuroendocrine tumors; chromogranin A; somatostatin receptors; microRNA; novel biomarkers; Molecular biology; Molekylärbiologi; Oncology; Onkologi; Virology; Virologi; Tumour biology; Tumörbiologi; Medical Science; Medicinsk vetenskap; Oncology; Onkologi; Medical Virology; Medicinsk virologi; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Neuroendocrine tumors (NETs), originally described as carcinoids, represent a rare and heterogeneous group of neoplasms associated with intensive secretion of hormones, bioactive peptides and amines. Most of the patients are diagnosed at a late stage of disease, often with liver metastases. LÄS MER

  5. 10. Genetic Aspects of Endocrine Tumorigenesis : A Hunt for the Endocrine Neoplasia Gene

    Författare :Alberto Delgado Verdugo; Peyman Björklund; gunnar westin; Per Hellman; Filip Farnebo; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Exome sequencing; SDHAF2; epigenetics; methylation; methylation array; Sanger sequencing; pheochromocytoma; SI-NETs; carcinoid; oncology; endocrine surgery; parathyroid; Genetics; Genetik; Kirurgi; Surgery;

    Sammanfattning : Endocrine tumors arise from endocrine glands. Most endocrine tumors are benign but malignant variants exist. Several endocrine neoplasms display loss of parts of chromosome 11 or 18, produce hormones and responds poorly to conventional chemotherapeutics. The multiple endocrine neoplasia syndromes are mainly confined to endocrine tumors. LÄS MER