Sökning: "cyclin-dependent kinase"

Visar resultat 1 - 5 av 49 avhandlingar innehållade orden cyclin-dependent kinase.

  1. 1. Pharmacological and analytical studies of the cyclin dependent kinase inhibitors

    Författare :Hatem H A Sallam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cyclin-dependent kinases (Cdks) play a key role in the regulation of cell cycle progression and RNA transcription. Deregulation of Cdks has been associated with several malignancies, neurodegenerative disorders, viral and protozoal infections, glomerulonephritis and inflammatory diseases. LÄS MER

  3. 2. Interferon-alpha signaling and cell cycle regulation in neuroendocrine tumors of the digestive system

    Författare :Yinghua Zhou; Uppsala universitet; []
    Nyckelord :Medical sciences; interferon-α; carcinoid tumors; interferon regulatory factor; p68; PKR; p21; p27; cell cycle; cyclin-dependent kinase; protein phosphorylation; protein trafficking; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : The prognosis for untreated carcinoid patients is poor and their quality of life is low. IFN-α treatment has shown a response rate of 50-80%, however, the antitumor mechanism has not been elucidated. LÄS MER

  4. 3. Interplay between the Myc oncoprotein, cyclin-dependent kinases and E3 ubiquitin ligases

    Författare :Hamid Reza Sharifi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mammalian cells grow, divide, and die in a precise and orderly fashion. For cells to grow and maintain their integrity they need to communicate at both intracellular and extracellular level. LÄS MER

  5. 4. Mechanisms of Medulloblastoma Dissemination and Novel Targeted Therapies

    Författare :Sara Bolin; Fredrik Swartling; Martine F. Roussel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medulloblastoma; Recurrence; MYC; SOX9; FBW7; Treatment; BET bromodomains; Cyclin-dependent kinases; Oncology; Onkologi;

    Sammanfattning : Medulloblastomas are the most frequent malignant childhood brain tumors, arising in the posterior fossa of children. The overall 5-year survival is 70%, although children often suffer severe long-term side effects from standard medical care. LÄS MER

  7. 5. Effect of cycline-dependent kinase and matrix metalloproteinase inhibitors on hematopoietic and leukemic cells

    Författare :Hairong Song; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rapid advances in molecular and cellular biology have improved the understanding of the mechanisms involved in leukemia development. Cyclin-dependent kinases (CDKs) and matrix metalloproteinases (MMPs) have been suggested as potential therapeutic targets and a number of pharmacologic inhibitors of CDKs and MMPs have been developed. LÄS MER