Sökning: "calcium channel"
Visar resultat 36 - 40 av 121 avhandlingar innehållade orden calcium channel.
36. Ion channels and electrical activity in vascular smooth muscle: Effects of calcium store depletion, cholesterol and cholesterol-lowering drugs
Sammanfattning : Smooth muscle cells (SMCs) in the vessel wall contract to regulate blood flow and pressure, a function essential for normal circulation through tissues. On the other hand, migration and proliferation of SMCs are important factors in vascular disease, such as atherosclerosis and restenosis following surgical dilatation. LÄS MER
37. On the Generation of cAMP Oscillations and Regulation of the Ca2+ Store-operated Pathway in Pancreatic Islet α- and β-cells
Sammanfattning : Insulin and glucagon are released in pulses from pancreatic β- and α-cells, respectively. Both cell types are electrically excitable, and elevation of the cytoplasmic Ca2+ concentration ([Ca2+]i) due to depolarization with voltage-dependent entry of the cation is the main trigger of hormone secretion. LÄS MER
38. Ion channels and intrinsic membrane properties of locomotor network neurons in the lamprey spinal cord
Sammanfattning : NMDA-receptor dependent membrane potential oscillations and postinhibitory rebound are examples of intrinsic membrane properties of many neurons of rhythm-generating networks, and are considered to play major roles in the operation of the spinal locomotor network of the lamprey vertebrate model. A significant feature of many lamprey spinal cord neurons is their ability to generate pacemaker-like membrane potential oscillations in the presence of the glutamate agonist NMDA. LÄS MER
39. Drug use in the elderly : risk or protection? Findings from the Kungsholmen project
Sammanfattning : This thesis deals with different aspects of drug use in a population-based study with participants 75 years and older. The study was performed within the Kungsholmen Project in Stockholm, Sweden, using data from the baseline survey (1987-89), and the first (1991-93) and second (1994-96) followups In the first two papers we used cross-sectional data (n=1810) to describe tile drug Ilse pattern ill this population (I), and to examine the association between self-reported symptoms and drug use (II). LÄS MER
40. Modulation of cellular mechanisms in a spinal locomotor network
Sammanfattning : Neuronal networks generate behaviour. Thus, to understand behaviour requires information on how neuronal networks work in terms of their cellular components. The overall aim of this work has been to link processes occurring at an ionic level to the operation of a neural network specialized for undulatory locomotion. LÄS MER
