Sökning: "calcium channel"

Visar resultat 31 - 35 av 121 avhandlingar innehållade orden calcium channel.

  1. 31. Skeletal muscle calcium homeostasis during fatigue : modulation by kinases and mitochondria

    Författare :Jan Aydin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The use of skeletal muscles in daily activities and even during strenuous exercise resulting in fatigue requires precise regulation of force and the timing of contraction. To achieve such performance characteristics, vertebrate skeletal muscles have developed a unique control mechanism for regulating the free Ca2+ concentration in their myoplasm ([Ca2+]i). LÄS MER

  3. 32. Molecular mechanisms involved in the generation of calcium signals in insulin secreting cells

    Författare :Kalaiselvan Krishnan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Intracellular Ca 2+ regulates diverse cellular functions in almost all the cells. In the pancreatic ß-cells, Ca 2+ signals are critical for insulin secretion. An increase in the cytoplasmic free Ca 2+ concentration ([Ca 2+ ]i) triggers insulin secretion. LÄS MER

  4. 33. New insights in parathyroid hormone secretion : with focus on exocytosis and calcium signaling

    Författare :Ming Lu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The parathyroid is distinguished from other endocrine systems since its primary stimuli inhibit hormone secretion. It is generally considered that extracellular Ca2+ binds to a membrane receptor (calcium sensing receptor, or CaSR), and via second messengers modulate parathyroid hormone (PTH) secretion. LÄS MER

  5. 34. The role of T-type calcium channels in human pancreatic β cell maturity

    Författare :Kaixuan Zhao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This PhD work has optimized a series of in vivo, ex vivo and in vitro approaches to recapitulate, intervene and appraise in vivo maturation of naïve β cells within human induced pluripotent stem cell-derived islets (hiPSC-islets). These approaches have also been applied to characterize hyperglycemia-induced dedifferentiation of mature β cells within native human islets grafted into the anterior chamber of the eye (ACE) of immunodeficient mice. LÄS MER

  7. 35. Antiarrhythmic and arrhythmic effects of an Ikr-blocking class III agent. A clinical and electrocardiographic study of almokalant

    Författare :Birgitta Houltz; Göteborgs universitet; []
    Nyckelord :Almokalant; class III antiarrhythmic agent; potassium channel blocker; atrial fibrillation; sinus rhythm; conversion; electrocardiographic; QT interval prolongation; T wave morphology; prediction; torsades de pointes; proarrhythmia; QT dispersion; ventric;

    Sammanfattning : The interest in class III drugs has increased over the last decades as being potent antiarrhythmic agents in their mode of action by prolongation of repolarization and with no effect on conduction. Class I antiarrhythmic agents have proven effective in conversion of atrial fibrillation (AF), but may cause serious proarrhythmia. LÄS MER