Sökning: "Orai1"

Hittade 4 avhandlingar innehållade ordet Orai1.

  1. 1. On the Generation of cAMP Oscillations and Regulation of the Ca2+ Store-operated Pathway in Pancreatic Islet α- and β-cells

    Författare :Geng Tian; Erik Gylfe; Anders Tengholm; Patrick Gilon; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP; oscillations; adrenaline; GLP-1; phosphodiesterase; palmitate; STIM1; Orai1; store-operated calcium entry; insulin secretion; glucagon secretion; β-cell; α-cell; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Insulin and glucagon are released in pulses from pancreatic β- and α-cells, respectively. Both cell types are electrically excitable, and elevation of the cytoplasmic Ca2+ concentration ([Ca2+]i) due to depolarization with voltage-dependent entry of the cation is the main trigger of hormone secretion. LÄS MER

  3. 2. Functional assays for the diagnosis of primary defects in lymphocyte cytotoxicity

    Författare :Samuel C C Chiang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytotoxic lymphocytes encompass natural killer (NK) cells and cytotoxic T lymphocytes (CTL). These cells detect and kill virus-infected as well as malignant cells. Primary defects in lymphocyte cytotoxicity are associated with development of a hyperinflammatory syndrome termed hemophagocytic lymphohistiocytosis (HLH). LÄS MER

  4. 3. New insights in parathyroid hormone secretion : with focus on exocytosis and calcium signaling

    Författare :Ming Lu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The parathyroid is distinguished from other endocrine systems since its primary stimuli inhibit hormone secretion. It is generally considered that extracellular Ca2+ binds to a membrane receptor (calcium sensing receptor, or CaSR), and via second messengers modulate parathyroid hormone (PTH) secretion. LÄS MER

  5. 4. Computational analysis on the effects of variations in T and B cells. Primary immunodeficiencies and cancer neoepitopes

    Författare :Gabriel Ndipagbornchi Teku; Proteinbioinformatik; []
    Nyckelord :Network topology; Network dynamics; network modeling; Network Simulation; T cells; B cells; Neoepitopes; Neoantigens; cancer;

    Sammanfattning : Computational approaches are essential to study the effects of inborn and somatic variations. Results from such studies contribute to better diagnosis and therapies. Primary immunodeficiencies (PIDs) are rare inborn defects of key immune response genes. Somatic variations are main drivers of most cancers. LÄS MER