Sökning: "Almokalant"
Hittade 3 avhandlingar innehållade ordet Almokalant.
1. Antiarrhythmic and arrhythmic effects of an Ikr-blocking class III agent. A clinical and electrocardiographic study of almokalant
Sammanfattning : The interest in class III drugs has increased over the last decades as being potent antiarrhythmic agents in their mode of action by prolongation of repolarization and with no effect on conduction. Class I antiarrhythmic agents have proven effective in conversion of atrial fibrillation (AF), but may cause serious proarrhythmia. LÄS MER
2. Teratogenicity as a consequence of drug-induced embryonic cardiac arrhythmia : Common mechanism for almokalant, sotalol, cisapride, and phenytoin via inhibition of IKr
Sammanfattning : During the last years, drugs that prolong the repolarisation phase of the myocardial action potential, due to inhibition of the rapid component of the delayed-rectifying potassium channel (IKr) have been in focus. In addition to arrhythmogenic potential, selective Ikr-blockers have also been shown to be embryotoxic and teratogenic in animal studies. LÄS MER
3. Structure and function of hepatic cytochromes P450 : implications for drug development
Sammanfattning : Prediction of human drug metabolism in vivo by use of in vitro systems is of immense importance in drug development since it allows avoidance of drugs coming out on the market that are subjected to interindividual variability in metabolism or causes drug-drug interactions, both of which in turn can lead to adverse drug reactions and result in non-optimal treatment. In the present investigations the importance of P450 haplotype on substrate specificity was studied as well as a comparison of different in vitro systems for optimal prediction of in vivo drug metabolism. LÄS MER