Sökning: "QT interval prolongation"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden QT interval prolongation.

  1. 1. Antiarrhythmic and arrhythmic effects of an Ikr-blocking class III agent. A clinical and electrocardiographic study of almokalant

    Författare :Birgitta Houltz; Göteborgs universitet; []
    Nyckelord :Almokalant; class III antiarrhythmic agent; potassium channel blocker; atrial fibrillation; sinus rhythm; conversion; electrocardiographic; QT interval prolongation; T wave morphology; prediction; torsades de pointes; proarrhythmia; QT dispersion; ventric;

    Sammanfattning : The interest in class III drugs has increased over the last decades as being potent antiarrhythmic agents in their mode of action by prolongation of repolarization and with no effect on conduction. Class I antiarrhythmic agents have proven effective in conversion of atrial fibrillation (AF), but may cause serious proarrhythmia. LÄS MER

  3. 2. Cardiovascular aspects on chronic obstructive pulmonary disease : with focus on ischemic ECG abnormalities, QT prolongation and arterial stiffness

    Författare :Ulf Nilsson; Anne Lindberg; Anders Blomberg; Bengt Johansson; Christine Brulin; Per Bakke; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epidemiology; COPD; ischemic heart disease; cardiovascular disease; ECG; spirometry; kardiologi; Cardiology;

    Sammanfattning : Background: Chronic Obstructive Pulmonary disease (COPD) is an under-diagnosed disease with a prevalence of approximately 10%, highly dependent on age and smoking habits. Comorbidities are common in COPD and of these, cardiovascular diseases (CVD) are the most common. LÄS MER

  4. 3. Pharmacokinetic, efficacy and safety modeling of new treatments against drug-resistant tuberculosis

    Författare :Lénaïg Tanneau; Mats Karlsson; Elin Svensson; Italo Poggesi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; pharmacometrics; nonlinear mixed effect models; tuberculosis; drug-resistance; bedaquiline; delamanid; metabolite; drug-drug interactions; QTc interval; transaminases; time-to-positivity; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Tuberculosis (TB) is an ancient infectious disease that remains one of the greatest killers on the planet. Its eradication is impeded by the development of resistance to first-line treatment. Each year half a million patients are infected with drug-resistant (DR) TB. LÄS MER

  5. 4. Improving assessment of cardiovascular arrhythmic safety of new pharmacologic agents

    Författare :Lars Johannesen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Fourteen drugs have been removed from the market worldwide due to an increased risk of torsade de pointes (TdP), a potentially fatal ventricular arrhythmia. Almost all of the removed drugs that have been linked to an increased risk for TdP have been shown to block the human ether-à-go-go-related gene (hERG) potassium channel. LÄS MER

  7. 5. Risks and risk monitoring in sotalol therapy for atrial fibrillation

    Författare :Hanna Lenhoff; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Atrial fibrillation (AF) stands as the most prevalent arrhythmia, significantly impacting both the prognosis and symptomatology of affected individuals. Healthcare expenditures associated with AF treatment and its related complications, in terms of morbidity and mortality, are substantial. LÄS MER