Sökning: "brain tumor development"
Visar resultat 1 - 5 av 126 avhandlingar innehållade orden brain tumor development.
1. Novel Regulators of Brain Tumor Development : – From neural stem cell differentiation to in vivo models
Sammanfattning : Malignant brain tumors are diseases with poor prognosis and/or severe long-term side effects of treatment. This thesis aimed to discover novel regulators in brain tumor development, based on studying neural stem cell and progenitor cell (NSPC) differentiation and using animal models to introduce new insights to mechanisms of human brain tumors. LÄS MER
2. Heparan Sulfate Proteoglycans in Brain Tumor Development
Sammanfattning : Malignant brain tumors are aggressive neoplasms that remain challenging to treat in spite of their detailed molecular characterization. Both adults and children may suffer from brain tumors, which, if not lethal, can cause severe long-term and devastating side effects. LÄS MER
3. Beyond Survival - Cognition after Pediatric Brain Tumor
Sammanfattning : Background: Pediatric Brain Tumor (PBT) survivors suffer from cognitive sequelae, especially within the areas of cognitive tempo, attention, executive function and memory. The cognitive difficulties are often accentuated over the years, but knowledge about the long term trajectory is still scarce. LÄS MER
4. Screening for Candidate Brain Tumor Genes : Identifying Genes that Cooperate with Platelet-Derived Growth Factor in Glioma Development and Progression
Sammanfattning : Malignant primary brain tumors, gliomas, often overexpress both platelet-derived growth factor (PDGF) ligands and receptors providing an autocrine and/or paracrine boost to tumor growth. Glioblastoma multiforme (GBM) is the most frequent glioma. Its aggressive and infiltrative growth renders it extremely difficult to treat. LÄS MER
5. Brain development in a dish
Sammanfattning : This thesis shows the path I took in the quest for modeling the brain, as the title says, in a dish. The introduction of induced pluripotent stem cells (iPSCs) as means to research biological processes has opened up whole new fields of study and unprecedented possibilities of generating human cells in vitro. LÄS MER