Sökning: "bispecific"

Visar resultat 16 - 20 av 26 avhandlingar innehållade ordet bispecific.

  1. 16. Antibody-based Cancer Immunotherapy : Personalization, response prediction and safety considerations

    Författare :Mohamed Eltahir; Sara Mangsbo; Patrick Micke; Gustav Ullenhag; Marit Inderberg; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : Antibody-based therapeutics have remarkably improved the field of immuno-oncology. Multiple monoclonal antibodies (mAbs) are approved for clinical use, and numerous antibodies are under clinical development. The scope of this thesis is to study the personalization of antibody-based immunotherapeutics and tools to predict their efficacy and safety. LÄS MER

  3. 17. Affibody molecules targeting HER3 for cancer therapy

    Författare :Tarek Bass; Stefan Ståhl; Christina Furebring; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affibody molecule; cancer therapy; epidermal growth factor receptors; ErbB3; HER3; protein engineering;

    Sammanfattning : The development of targeted therapy has contributed tremendously to the treatment of patients with cancer. The use of highly specific affinity proteins to target cancer cells has become a standard in treatment strategies for several different cancers. LÄS MER

  4. 18. Generation and characterization of Affibody molecules targeting HER3

    Författare :Magdalena Malm; Stefan Ståhl; Jennifer Cochran; KTH; []
    Nyckelord :Affibody molecules; epidermal growth factor receptors; HER3; ErbB3; combinatorial protein engineering; combinatorial library; staphylococcal surface display;

    Sammanfattning : In the field of oncology, the ability to target specific tumor cells using highly selective targeting molecules is an attractive and emerging concept. In this context, the epidermal growth factor receptor HER3 has proven central to the biology behind many different human cancers and inhibition of the signaling mediated by this receptor could provide antitumoral effects. LÄS MER

  5. 19. Microwell devices for single-cell analyses

    Författare :Sara Lindström; Helene Andersson-Svahn; Mehmet Toner; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; microwell; miniaturization; microfluidics; cell culture; single-cell; clone; imaging; stem cell; cancer; low volume; high-throughput; Molecular biology; Molekylärbiologi;

    Sammanfattning : Powerful tools for detailed cellular studies are emerging, increasing the knowledge ofthe ultimate target of all drugs: the living cell. Today, cells are commonly analyzed inensembles, i.e. thousands of cells per sample, yielding results on the average responseof the cells. LÄS MER

  7. 20. Cell line and protein engineering tools for production and characterization of biologics

    Författare :Anna-Luisa Volk; Johan Rockberg; Mathias Uhlen; Dickson Alan; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Pharmaceutical proteins; precision medicine; antibody engineering; epitope mapping; cell line development; split-GFP; Bioteknologi; Biotechnology;

    Sammanfattning : Our increasing understanding of disease mechanisms coupled with technological advances has facilitated the generation of pharmaceutical proteins, which are able to address yet unmet medical needs. Diseases that were fatal in the past can now be treated with novel biological medications improving and prolonging life for many patients. LÄS MER