Sökning: "syndecan"

Visar resultat 1 - 5 av 26 avhandlingar innehållade ordet syndecan.

  1. 1. Syndecan-1 insights in mesothelioma

    Författare :Ghazal Heidari-Hamedani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Syndecan-1 is a cell surface heparan sulfate proteoglycan expressing on epithelial cells. Heparan sulfate (HS) chains on syndecan-1 constitute growth factor attachment sites and facilitate growth factors to bind their respective receptors. This binding property of HS chains allows syndecan-1 to be involved in various cellular processes. LÄS MER

  3. 2. Circulating proteoglycans and glycosaminoglycans during critical illness

    Författare :Axel Nelson; Anestesiologi och intensivvård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heparan sulphate; glycocalyx; hyaluronic acid; syndecan; permeability; antimicrobial;

    Sammanfattning : The endothelial glycocalyx is the carbohydrate rich inner layer of the blood vessels. Important components of the glycocalyx are the proteoglycans with their attached glycosaminoglycans. LÄS MER

  4. 3. Role of Heparan Sulfate N-sulfation in Mouse Embryonic Development

    Författare :Anders Dagälv; Lena Kjellén; Svein Kolset; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heparan sullfate; heparin; proteoglycan; NDST1; NDST2; coreprotein; syndecan; Biochemistry; Biokemi; Cell biology; Cellbiologi; Biokemi; Biochemistry;

    Sammanfattning : Heparan sulfate (HS) is a sulfated glycosaminoglycan expressed by all cells in the body. It is found at the cell surface and in the extracellular matrix where it binds a large amount of various ligands including growth factors and morphogens. LÄS MER

  5. 4. Endocytosis of therapeutic macromolecules in tumor cells - Mechanistic aspects of the proteoglycan receptor function

    Författare :Anders Wittrup; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LL-37; heparan sulfate; glypican; endocytosis; drug delivery; DNA uptake; Cancer; cell penetrating peptides; non-viral gene delivery; organelle purification; proteoglycan; syndecan.;

    Sammanfattning : Novel therapeutics to combat cancer are urgently needed. Most current pharmacological therapies have severe side effects and are seldom curative. Macromolecular drugs, and in particular nucleic acid based drugs, offer a potential remedy for this situation. LÄS MER

  7. 5. Studies on syndecan-1 in mesenchymal tumors

    Författare :Fang Zong; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The syndecans are a four-member family of type I transmembrane proteoglycans. Their core proteins have a short cytoplasmic domain, a transmembrane domain and a large N-terminal extracellular domain possessing glycosaminoglycan chains. All the protein domains and the glycosaminoglycan chains can contribute to the functions of syndecans. LÄS MER