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Visar resultat 1 - 5 av 37 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Antibiotic Resistance : Selection in the Presence of Metals and Antimicrobials

   Författare :Lisa M. Albrecht; Dan I Andersson; Alex O'Neill; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance; Metals; Antimicrobials; Bacterial evolution; Bacterial genetics; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

   Sammanfattning : The external environment is complex: Antibiotics, metals and antimicrobials do not exist in isolation but in mixtures. Human activities such as animal husbandry, fertilization of agricultural fields and human medicine release high amounts these compounds into the environment. LÄS MER

3. 2. Antibiotic-induced Bacterial Toxin Release – Inhibition by Protein Synthesis Inhibitors

   Författare :Gunilla Hjerdt-Goscinski; Jan Sjölin; Monica Lundholm; Inga Odenholt; Ingrid Nilsson-Ehle; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Communicable diseases; Endotoxin; LPS; exotoxin; SpeA; penicillin-binding protein; aminoglycosides; clindamycin; β-lactam antibiotics; severe sepsis; septic shock; Infektionssjukdomar; Infectious diseases; Infektionssjukdomar;

   Sammanfattning : Toxic products, such as endotoxin from the gram-negative and exotoxin from the gram-positive bacteria, are the most important initiators of the inflammatory host response in sepsis. In addition to antibacterial treatment, numerous attempts have been made to interfere with the exaggerated proinflammatory cascade initiated by the toxins. LÄS MER

4. 3. Bioactive Surgical Implant Coatings with Optional Antibacterial Function

   Författare :Mirjam Lilja; Maria Strømme; Håkan Engqvist; Håvard Haugen; Uppsala universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Hydroxyapatite; titanium dioxide; photocatalysis; antibacterial effect; antibiotic release; biomimetic coating; co-precipitation; tobramycin;

   Sammanfattning : Device associated infections are a growing problem in the field of orthopaedics and dentistry. Bacteria adhering to implant surfaces and subsequent biofilm formation are challenging to treat with systemic administered antibiotics. LÄS MER

5. 4. Multifunctional Polymer Materials: From Synthesis to Disinfection

   Författare :Haiyue Gong; Tillämpad biokemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecularly imprinted polymer; Antibacterial; Ag nanoparticles; Antibiotic; Boronic acid; Polyethylenimine; Quaternary ammonium;

   Sammanfattning : Polymer materials have wide applications in many industries, such as the food, pharmacy, construction, textile, and cosmetics industries. For the past few years, polymer materials have drawn the attention of scientists and engineers as a good disinfectant due to their advanced manufacturing methods, large surface areas, good stability, and lowcost. LÄS MER

7. 5. A strategy to identify novel antimicrobial compounds : a bioinformatics and HTS approach

   Författare :Sara Garbom; Hans Wolf-Watz; Dan Andersson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibiotic resistance; Yersinia; T3SS; virulence associated genes; VagH; HemK PrmC; Release factors; small molecular inhibitors; HTS; Medical microbiology; Medicinsk mikrobiologi;

   Sammanfattning : Bacterial infections are again becoming difficult to treat because the microbes are growing increasingly resistant to the antibiotics in use today. The need for novel antimicrobial compounds is urgent and to achieve this new targets are crucial. In this thesis we present a strategy for identification of such targets via a bioinformatics approach. LÄS MER