Sökning: "anti-cancer drugs"
Visar resultat 1 - 5 av 80 avhandlingar innehållade orden anti-cancer drugs.
1. Pharmacokinetics and Pharmacodynamics of Anti-Cancer Regimens : Emphasis on Busulphan and the Combination Therapies Epirubicin-Docetaxel and Fluorouracil-Epirubicin-Cyclophosphamide
Sammanfattning : Although the main reason for the lack of distinct dose-response and -toxicity relationships for anti-cancer agents is due to variability in pharmacodynamics, variability in pharmacokinetics may also contribute. Hence, not only describing and quantifying the relationship between pharmacokinetics and dose-limiting toxicities, but characterising the pharmacokinetics and its associated variability are of obvious importance in the process of developing dosing strategies for anti-cancer regimens. LÄS MER
2. Preclinical tumor-immune modeling : For the identification of immunomodulatory drugs
Sammanfattning : For a long time, the field of cancer research was dominated by a tumor cell-centric view. That, however, changed once it became recognized that medical cancer treatment is largely influenced by the combined effect exerted on both cancer and immune cells. LÄS MER
3. Mechanisms determining efficacy of tyrosine kinase-targeting anti-cancer drugs
Sammanfattning : The expanding field of cancer research and the introduction of multiple molecular biology techniques have significantly improved cancer drug discovery, presented new drugs, including tyrosine kinase inhibitors, and thereby gave new hope to the cancer patients and their oncologists. Using this knowledge it is now becoming increasingly possible to determine outcome of malignant disease more accurately, to estimate response to specific therapies and to get closer to the ideal of personalized targeted therapy adjusted to each patient, and to the specific cancer type and its unique genetic profile. LÄS MER
4. Autophagy and VPS34 as targets in anti-cancer therapy
Sammanfattning : Autophagy (Greek for self-eating) is a cellular pathway that breaks down cytoplasmic components to fuel metabolism. In this way, autophagy maintains cellular homeostasis and sustains survival during stress conditions. In cancer, autophagy is often dysregulated and has been described to contribute to malignancy and therapy resistance. LÄS MER
5. Analyses of Dose-Response and Mechanistic Action of Different Anti-Cancer Drugs for Neuroendocrine Tumor Cell Lines
Sammanfattning : Cancer is a disease with poor response rates on available treatments. Problems with resistance and intolerance against cancer drugs are major reasons for failure of the drugs. The need to discover new cancer drugs is important. In this thesis screening of new cancer drugs and evaluation of their mechanism of action are discussed. LÄS MER
