Sökning: "Biosynthesis amyloid"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Biosynthesis amyloid.
1. Proislet Amyloid Polypeptide (proIAPP) : Impaired Processing is an Important Factor in Early Amyloidogenesis in Type 2 Diabetes
Sammanfattning : Amyloid is defined as extracellular protein aggregates with a characteristic fibrillar ultra-structure, Congo red affinity and a unique x-ray diffraction pattern. At present, 25 different human amyloid fibril proteins have been identified, and amyloid aggregation is associated with pathological manifestations such as Alzheimer’s disease, spongiform encephalopathy and type 2 diabetes. LÄS MER
2. Polysaccharides in Alzheimer's disease and inflammation-associated amyloidosis
Sammanfattning : Amyloidosis is a term for diseases that share a common feature: the extracellular deposition of amyloid fibrils, that consist of a single protein prone to aggregate. Polysaccharides (glycos-aminoglycans), especially heparan sulfate, are significant components of all types of amyloid deposits. LÄS MER
3. Molecular mechanisms in amyloid fibril formation
Sammanfattning : This thesis concerns investigations on molecular processes and interactions that lead to amyloid fibril formation. Pulmonary surfactant protein C (SP-C), and a synthetic analogue thereof, SP-C(Leu), have similar properties in terms of charge distribution, hydrophobicity and secondary structure, yet they differ in their aggregation propensities. LÄS MER
4. Amyloid precursor protein : cellular studies and animal models
Sammanfattning : Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by a number of neuropathological features, including extracellular deposits composed primarily of amyloid-β (Aβ) peptides. Aβ is derived from proteolysis of the amyloid precursor protein (APP) by consecutive action of β and γ-secretases. LÄS MER
5. BRICHOS - a Novel Anti-Amyloid Chaperone : studies on pro-surfactant protein C
Sammanfattning : Lung surfactant protein C (SP-C) is a 35-residue, transmembrane (TM) peptide that is extremely hydrophobic and lacks known homologous proteins. Due to a high content in Val residues in the α-helical TM part, SP-C can spontaneously convert into β-sheet aggregates. LÄS MER