Sökning: "allogeneic DCs"

Visar resultat 11 - 15 av 17 avhandlingar innehållade orden allogeneic DCs.

  1. 11. NK cell education and adhesion molecules : implications for immunotherapy

    Författare :Arnika Kathleen Wagner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : NK cells have a key role in immune surveillance. They detect aberrant expression of stressinduced molecules and MHC class I molecules with an array of activating and inhibitory receptors. LÄS MER

  3. 12. Pathophysiological aspects of transplantation-related complications following busulphan/cyclophosphamide conditioning regimen in mouse model

    Författare :Sulaiman Al-Hashmi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Busulfan;

    Sammanfattning : Hematopoietic stem cell transplantation (HSCT) is a curative treatment for several malignant and non-malignant disorders. However, transplantation related morbidity and mortality limit its use. The complications of the HSCT procedure can be caused by several factors including toxicity of the conditioning regimen and allogeneicity. LÄS MER

  4. 13. Exosomes : immunomodulators in cancer and therapy

    Författare :Stefanie Hiltbrunner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Exosomes are nano-sized membrane vesicles derived from the late endosomal compartment. They are capable of transferring proteins, lipids and RNA between cells. B cell and dendritic cell (DC)-derived exosomes express major histocompatibility complex (MHC) class I and II, as well as costimulatory molecules (CD80/86) and can initiate T cell responses. LÄS MER

  5. 14. Natural killer cell inhibitory and activating receptors : regulatory role in effector functions against normal and tumor cells

    Författare :Gustaf Vahlne; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Natural killer (NK) cells can mediate effector functions as cytokine production and degranulation dependent cytotoxicity against cells that have become aberrant by mutagenesis or by infection. As part of the innate immunity, the NK cells are most important in the direct early defense against infections, and also in indirect shaping of the later adaptive response. LÄS MER

  7. 15. The Multiple Faces of Genetically-Modified T Cells : Potential Applications in Therapy

    Författare :Victoria Hillerdal; Magnus Essand; Johanna Olweus; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer immunotherapy; genetically engineered T cells; chimeric antigen receptor; T cell receptor; antigen-specific T cells; immunotherapy; Immunologi; Immunology; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : In this PhD thesis the potential of T-cells as therapy for disease are explored. The applications of genetically modified T-cells for treatment of cancer and autoimmune disease; the functionality and optimal activation of T-cells are discussed. LÄS MER