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Visar resultat 16 - 20 av 66 avhandlingar som matchar ovanstående sökkriterier.

  1. 16. Synthesis of oligosaccharides related to the capsular polysaccharide of Neisseria meningitidis serotype A

    Författare :Peter Teodorovic; Stefan Oscarson; Mikael Elofsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi;

    Sammanfattning : In order to find suitable stable vaccine candidates against Neisseria meningitidis group A, several structures related to the capsular polysaccharide have been synthesised. The first part of the thesis describes the synthesis of C-phosphonate analogues starting from glucose. LÄS MER

  3. 17. Synthesis, conformational analysis, and biological evaluation of peptides from E. coli P pilus proteins

    Författare :Katarina Flemmer Karlsson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NMR spectroscopy; CD spectroscopy; peptide structure; ELISA; solid-phase peptide synthesis; peptide; P pili; chaperone; Organic chemistry; Organisk kemi;

    Sammanfattning : Many bacteria utilize hairlike protein appendages (pili) to attach themselves to mucosal cell surfaces in the host organism. The pilus is assembled from protein subunits synthesized inside the bacteria and transported to the outer cell wall for incorporation into the growing pilus. LÄS MER

  4. 18. Multifaceted adhesion properties of Helicobacter pylori in promotion of gastric disease

    Författare :Jenny Nordén; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Helicobacter pylori is a Gram-negative spiral-shaped bacteria that resides in the gastric mucosa and adheres to the epithelial lining of the human stomach. H. pylori adhesion mediates inflammation of the epithelium, which can lead to more severe diseases such as chronic active gastritis and gastric carcinoma. LÄS MER

  5. 19. Interaction between gastric pathogen Helicobacter pylori and host cells

    Författare :Bin Su; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Helicobacter pylori; receptors; Lewis blood group antigen; MCP; integrin and signals;

    Sammanfattning : H. pylori plays a causative role in the pathogenesis of gastritis, gastric atrophy, gastric and duodenal ulcer, and is believed to predispose to gastric adenocarcinoma as well as low-grade B-cell lymphoma. Lewisb (Leb) blood group antigen is a receptor for Leb adhesin-positive H. pylori strains. LÄS MER

  7. 20. Improved detection and performance of surface expression from the AIDA-I autotransporter

    Författare :Johan Jarmander; Gen Larsson; Ulrika Rova; Ines Ezcurra; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; surface expression; autotransport; AIDA-I; Escherichia coli; proteolysis; detection tag;

    Sammanfattning : Surface expression of recombinant proteins has attracted a lot of attention due to its potential in applications such as enzyme production, vaccine delivery and bioremediation. Autotransporters have been used for surface expression of a variety of proteins, but the expression systems reported in literature have typically been inflexible and incapable of detecting proteolysis, thereby limiting surface expression yield. LÄS MER