Sökning: "P pili"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden P pili.

  1. 1. NMR as a tool in drug research : Structure elucidation of peptidomimetics and pilicide-chaperone complexes

    Författare :Mattias Hedenström; Jan Jan Kihlberg; Ingmar Sethson; Michael P. Williamson; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; NMR; structure calculations; peptidomimetics; desmopressin; Leu-enkephalin; chemical shift mapping; pilicides; chaperones; urinary tract infections.; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : In the last decades NMR spectroscopy has become an invaluable tool both in academic research and in the pharmaceutical industry. This thesis describes applications of NMR spectroscopy in biomedicinal research for structure elucidation of biologically active peptides and peptidomimetics as well as in studies of ligand-protein interactions. LÄS MER

  2. 2. Synthetic biology approaches for improving production of fatty acid-derived compounds in cyanobacteria

    Författare :Ivana Cengic; Elton P. Hudson; Mathias Uhlén; Annegret Wilde; KTH; []
    Nyckelord :ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; cyanobacteria; metabolic engineering; surface display; CRISPRi; fatty alcohols; fatty acid synthesis; aldehyde deformylating oxygenase; Bioteknologi; Biotechnology;

    Sammanfattning : The environmental consequences associated with the use of fossil-sourced fuels and chemicals have brought with it a realization that future development must move in a more sustainable direction. Currently available biofuels or renewably produced chemical, such as bioethanol or biodiesel, are produced from microbial fermentation of sugar-rich crops or by chemical conversion of natural oils or fats. LÄS MER

  3. 3. Synthesis, conformational analysis, and biological evaluation of peptides from E. coli P pilus proteins

    Författare :Katarina Flemmer Karlsson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NMR spectroscopy; CD spectroscopy; peptide structure; ELISA; solid-phase peptide synthesis; peptide; P pili; chaperone; Organic chemistry; Organisk kemi;

    Sammanfattning : Many bacteria utilize hairlike protein appendages (pili) to attach themselves to mucosal cell surfaces in the host organism. The pilus is assembled from protein subunits synthesized inside the bacteria and transported to the outer cell wall for incorporation into the growing pilus. LÄS MER

  4. 4. Construction of force measuring optical tweezers instrumentation and investigations of biophysical properties of bacterial adhesion organelles

    Författare :Magnus Andersson; Ove Axner; Lene Broeng Oddershede; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; optical tweezers; biological physics; unfolding; Escherichia coli; force measurements; energy landscape; dynamic force spectroscopy; manipulation; polymers; pili; Physics; Fysik;

    Sammanfattning : Optical tweezers are a technique in which microscopic-sized particles, including living cells and bacteria, can be non-intrusively trapped with high accuracy solely using focused light. The technique has therefore become a powerful tool in the field of biophysics. LÄS MER

  5. 5. The mechanics of adhesion polymers and their role in bacterial attachment

    Författare :Johan Zakrisson; Magnus Andersson; Ramser Kerstin; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; Pili; optical tweezers; bacterial adhesion; fimbriae; uncoiling;

    Sammanfattning : Bacterial resistance to antibiotics is increasing at a high rate in both developing and developed countries. To circumvent the problem of drug-resistant bacterial pathogens, we need to develop new effective methods, substances, and materials that can disarm and prevent them from causing infections. LÄS MER