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Visar resultat 1 - 5 av 47 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Imidazole containing polymers complexed with Cu2+ and Zn2+

    Författare :Markus Andersson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; vibrational spectroscopy; far-FTIR; EPR; cross-linking; DSC; Coordinating polymer; imidazole; mid-FTIR; metal ion;

    Sammanfattning : An enormous problem for the shipping industry is fouling of marine organisms such as algae andbarnacles on the boat hull. The negative consequences for the society are both economical as well asenvironmental. To prevent fouling in general, biocides are typically incorporated directly into the paint. LÄS MER

  3. 2. Peptide nucleic acid conjugates as artificial ribonucleases : Cu2+ and Zn2+-dependent PNAzymes

    Författare :Olivia Luige; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Synthetic modified oligonucleotides are gaining momentum as powerful therapeutic tools used in the treatment of life-threatening diseases. Degradation of disease-related RNA sequences is one of the goals achieved with oligonucleotide therapeutics, albeit the currently available technologies rely on the recruitment of endogenous enzymes, RNase H or RISC, limiting the chemical architecture of oligonucleotide drugs. LÄS MER

  4. 3. Molecular characterization of the Ro52 autoantigen and its disease related epitopes

    Författare :Lars Ottosson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ro52; Sjögren s syndrome; autoantibodies; congenital heart block; molecular characterization; TRIM; RBCC; Zn2 ;

    Sammanfattning : The presence of high titers of autoantibodies in patient sera is characteristic for the autoimmune disorder Sjögren s syndrome. The major targets for these autoantibodies are three intracellular proteins Ro52, Ro60 and La. It is still unclear why these proteins become targets for the immune system, and how this autoreactivity is triggered. LÄS MER

  5. 4. Polypeptide functionalized gold nanoparticles for bioanalytical applications

    Författare :Robert Selegård; Bo Liedberg; Karin Enander; Daniel Aili; Wilhelm Robert Glomm; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Detection strategies that allow for simple, rapid, cost efficient and sensitive monitoring of proteins and their interactions with biomolecules are of great importance in drug development and diagnostics. This thesis describes the development of bioanalytical applications based on the tunable self-assembly of gold nanoparticles functionalized with a de novo designed polypeptide. LÄS MER

  7. 5. Structural studies of metal-binding proteins revealing dynamic behaviour

    Författare :Maria Håkansson; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kemi; Chemistry; Molekylär biofysik; Molecular biophysics; zinc; magnesium; superantigen; calbindin D9k; X-ray crystallography; staphylococcal enterotoxin; structure; Chemical technology and engineering; Kemiteknik och kemisk teknologi;

    Sammanfattning : The Mg2+ and Mn2+ structures of calbindin D9k have been determined and they reveal a conformational change compared to the structures of apo and (Ca2+)2-calbindin D9k. These findings are unique, since normally calcium and not magnesium is known to induce conformational changes of EF-hand proteins. LÄS MER