Sökning: "Lars Ottosson"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Lars Ottosson.

  1. 1. Molecular characterization of the Ro52 autoantigen and its disease related epitopes

    Författare :Lars Ottosson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Ro52; Sjögren s syndrome; autoantibodies; congenital heart block; molecular characterization; TRIM; RBCC; Zn2 ;

    Sammanfattning : The presence of high titers of autoantibodies in patient sera is characteristic for the autoimmune disorder Sjögren s syndrome. The major targets for these autoantibodies are three intracellular proteins Ro52, Ro60 and La. It is still unclear why these proteins become targets for the immune system, and how this autoreactivity is triggered. LÄS MER

  2. 2. Cellular Resilience and Fragility in Response to Environmental and Gene Expression Perturbations

    Författare :Lars-Göran Ottosson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Saccharomyces cerevisiae; Phenomics; Liquid microcultivation; Tellurite; Gene overexpression; gToW; Cellular signalling; HOG; Protein phosphatase;

    Sammanfattning : Cells are constantly subjected to perturbations. Whether these are extracellular or intracellular, they can be detrimental to cellular fitness. The cell has evolved elaborate systems and mechanisms that allow it to remain functional in the face of disturbances. LÄS MER

  3. 3. Robustness analysis of eukaryotic signal transduction with emphasis on the HOG pathway in Saccharomyces cerevisiae

    Författare :Lars-Göran Ottosson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; systems biology; robustness; gTOW; signal transduction; MAPK signalling; HOG; kinase; phosphatase; transcription factor;

    Sammanfattning : Fundamental to life, in particular for unicellular microorganisms that generally are subjected to rapidly changing environmental parameters, is the need to monitor and integrate environmental stimuli with the internal cell status. The sensing of stimuli are typically initiated at the plasma membrane and then transmitted by means of intracellular signalling networks to elicit proper cellular responses. LÄS MER

  4. 4. "But can't you see they are lying" : student moral positions and ethical practices in the wake of technological change

    Författare :Lars-Erik Nilsson; Torgny Ottosson; Berner Lindström; Rupert Wegerif; Högskolan Kristianstad; []
    Nyckelord :SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Technology in education; positioning; ethical practices; Education; Pedagogik;

    Sammanfattning : Today it is considered important that modern digital technology be implemented and that all citizens learn to use it. Students already use mobile phones, personal digital assistants, computers, and their applications to do much of their work. This includes searching for and retrieving information, and collaborating on assignments and writing. LÄS MER

  5. 5. Upplevelser och lärande i äventyrssport och skola

    Författare :Johan Arnegård; Lars-Magnus Engström; Torgny Ottosson; Gymnastik- och idrottshögskolan; []
    Nyckelord :SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; adventure sports; risk sports; extreme sports; outdoor life; sportification process; leisure time culture; climbing; flow; habitus; learning; Education; Pedagogik;

    Sammanfattning : The physicality of sports and outdoor life offers great opportunities for intensive experiences – participants ”feel” the happening in their bodies. As well as looking upon physical activity mainly as something instrumental, as for example in competitive sports and exercise culture, other aspects can also be central, for instance the pure joy of movement. LÄS MER