Sökning: "Therapy-related disease"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Therapy-related disease.

  1. 1. Population-based studies in Myelodysplastic syndromes : Prognostic scores, socioeconomic status, and therapy-related disease

    Författare :Daniel Moreno Berggren; Elisabeth Ejerblad; Sören Lehmann; Martin Jädersten; David Bowen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Myelodysplastic syndromes; Chronic myelomonocytic leukaemia; Prognostication; Comorbidity; Therapy-related disease; Real-world data; Population-based studies; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The aim of this thesis was to expand the epidemiological knowledge of the haematological malignancy MDS and the related condition chronic myelomonocytic leukaemia (CMML). Using nationwide registers, the papers in this thesis address aspects of prognostication, comorbidity, socioeconomic status, and therapy-related disease, using a population-based approach. LÄS MER

  3. 2. Characterization of secondary and therapy-related acute myeloid leukemia

    Författare :Christer Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Secondary acute myeloid leukemia (s-AML) refers to patients with either therapy-related AML (t-AML), that is, AML after treatment with chemo- and/or radiation for a prior disease, or AML progressing from an antecedent hematologic disorder (AHD-AML), typically a myelodysplastic syndrome (MDS) or a myeloproliferative neoplasm. Patients with s-AML present with higher rates of adverse cytogenetic aberrations and higher frequencies of adverse mutations and, subsequently, respond worse to therapy, and have poorer outcome compared to de novo AML. LÄS MER

  4. 3. Cancer of unknown primary: searching for the etiological clues. A population-based epidemiological study in Sweden

    Författare :Xiaochen Shu; Allmänmedicin och klinisk epidemiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer of unknown primary; causes of death; familial risk; immigrant; incidence; multiple malignancies; risk factor; squamous cell carcinoma; standardizedincidence ratio; survival;

    Sammanfattning : This thesis aimed to search for etiological clues about cancer of unknown primary(CUP) by gathering novel information. The Swedish national registries were used and CUP cases were identified according to the seventh revision of the International Classification of Diseases. LÄS MER

  5. 4. Febrile Urinary Tract Infection: P fimbriae, Innate Host Response and Bacteremia

    Författare :Gisela Otto; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prsGJ96; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi; papGIA2; antibiotic therapy; urine; chemokine; interleukin-6; host response; P fimbriae; bacteremia; febrile urinary tract infection; Escherichia coli;

    Sammanfattning : Urinary tract infections (UTI) are among the most common human infections, and febrile UTI with bacteremia the most severe form. The relation between bacteria and host decides disease severity. The dominating uropathogen is Escherichia coli (E. coli). LÄS MER

  7. 5. Studies of side effects related to adjuvant breast cancer regimens with focus on chemotherapy

    Författare :Andri Papakonstantinou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Radiotherapy, endocrine therapy, chemotherapy and targeted therapy adjunct to surgery have a critical role in the management of early breast cancer for outcome improvement. Anthracycline containing chemotherapy reduces 10-year incidence of breast cancer mortality by an absolute 6. LÄS MER