Sökning: "T-cellsutveckling"
Hittade 3 avhandlingar innehållade ordet T-cellsutveckling.
1. Computational modelling in systems biology: from rewriting cell fates to detecting tumours
Sammanfattning : Computational modelling is becoming an increasingly important tool in biological research. By performing computer simulations of models, it becomes possible to test theories about a biological system against experimental data. Simulations can also be used as a replacement for experiments otherwise unattainable. LÄS MER
2. Aspects of T cell development contributing to autoimmunity
Sammanfattning : Autoimmunity, such as type 1 diabetes (T1D), arises as a result of tolerance breakdown against host tissues, i.e. the β-cells. Central tolerance is established during thymic T cell development and defects in key events during this process could contribute to the pathogenesis of autoimmune diseases. LÄS MER
3. DNA methylation in T cell leukaemia
Sammanfattning : T cell acute lymphoblastic leukaemia (T-ALL) is a predominantly paediatric cancer that stems from malignant transformation of developing T cells. While the disease has an overall survival rate of 80%, the intense chemotherapy treatment causes severe toxicity and long-term side effects. LÄS MER