Sökning: "Subcutaneous administration"

Visar resultat 1 - 5 av 44 avhandlingar innehållade orden Subcutaneous administration.

  1. 1. Development and characterization of an in vitro method for interaction studies between polymers and pharmaceuticals : Aiding in the development of new drug delivery systems

    Författare :Marcus Wanselius; Per Hansson; Magnus Bergström; Susanna Abrahmsén-Alami; Christian Pedersen; Anna Fureby; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microgels; Subcutaneous administration; Drug delivery; Microfluidics; In vitro methodology; Method development; Biopharmaceuticals; Amphiphilic drugs; Polyelectrolytes; Hyaluronic acid; Peptides; Farmaceutisk fysikalisk kemi; Pharmaceutical Physical Chemistry;

    Sammanfattning : Polymers are a group of macromolecules used in formulations of pharmaceuticals, one example being the delivery system DC Bead™. Further, some of the most abundant and for drug delivery important constituents of the subcutaneous tissue are charged polymers (polyelectrolytes), e.g. collagen, hyaluronic acid, and chondroitin sulfate. LÄS MER

  3. 2. Glucocorticoid administration : studies on weight regulation and metabolic implications

    Författare :Joanna Uddén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Glucocorticoids; leptin; obesity; adipose tissue; PAI-1; UCP-2; cortisol; the metabolic syndrome; 11 beta-HSD; eating behaviour; weight gain.;

    Sammanfattning : Long-term treatment with glucocorticoids induces weight gain and increased risk to develop obesity-related metabolic complications like insulin resistance, type 2 diabetes and cardiovascular disease. Glucocorticoids have been suggested to play a role in development of visceral fat accumulation. LÄS MER

  4. 3. Risk Factors for Diabetic Ketoacidosis in Children

    Författare :Johan H Wersäll; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetic ketoacidosis; Type 1 diabetes; Continuous subcutaneous insulin infusion; Multiple daily injections; Cerebral edema; Socioeconomic status; Low economic standard; Level of education;

    Sammanfattning : Background: Diabetic ketoacidosis (DKA) is a life-threatening acute complication of diabetes. It is preventable if timely administration of sufficient amounts of insulin is initiated. A large proportion of children are affected by DKA annually, especially at onset of type 1 diabetes (T1D). LÄS MER

  5. 4. Central venous access devices in patients with haematological malignancies care, complications and home treatment

    Författare :Eva Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Central venous access devices; haematological malignancies; dressing changes; self-administration; ambulatory; stem cell collection;

    Sammanfattning : A well functioning central venous access device (CVAD) that will remain in situ free from complications during the entire treatment period, is highly desirable in the management of patients with aggressive haematological malignancies. Unfortunately, such a goal is not likely to be achieved due to the high rate of CVAD-related complications. LÄS MER

  7. 5. Neuropeptide Y - aspects of vasomotorresponses and receptor characterization

    Författare :Torun Nilsson-Bergdahl; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vasoconstriction; RT-PCR; receptor characterization; potentiation; NPY Y1 receptor; NPY; mitogenesis; hypertension; human arteries; forearm blood flow; cell culture; antisense oligodeoxynucleotides; BIBP3226; vasodilatation.; Physiology; Fysiologi; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : Abstract The aims of the present thesis were to examine neuropeptide Y (NPY) responses in different human and guinea pig vascular beds and in cultured human vascular smooth muscle cells (VSMC) and to characterize, with different NPY agonists and the specific NPY Y1 receptor antagonist (BIBP3226), the NPY receptors involved. NPY-induced strong and potent contractions in human cerebral and subcutaneous arteries and in guinea pig basilar arteries. LÄS MER