Sökning: "Biopharmaceuticals"

Visar resultat 1 - 5 av 32 avhandlingar innehållade ordet Biopharmaceuticals.

1. 1. Design and Control of Integrated Continuous Processes for the Purification of Biopharmaceuticals

   Författare :Joaquin Gomis Fons; Avdelningen för kemiteknik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Integrated Continuous Biomanufacturing; Downstream Processing; Process Design and Optimization; Process Control; Biopharmaceuticals;

   Sammanfattning : The production of biopharmaceuticals so far has been based on batch processes that are robust and well-known, but very inefficient and inflexible, causing the products to be very expensive and process development to be slow and costly. The production of biopharmaceuticals is thus changing towards integrated continuous biomanufacturing (ICB) in order to reduce costs and increase flexibility in a constantly changing market. LÄS MER

3. 2. Development of immunogenicity models in mice for improved risk assessment of biopharmaceuticals

   Författare :Britta Granath; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; anti-drug antibodies; immunogenicity; biopharmaceuticals; immunoglobulin; 3R;

   Sammanfattning : The development of anti-drug-antibodies (ADA) to biopharmaceuticals, e.g. recombinant proteins including monoclonal antibodies (mAb) can lead to adverse events and clinical complications. These include reduced effect of the drug and autoimmune conditions if the administered drug is analogous to endogenous proteins. LÄS MER

4. 3. Tools for digital twins in continuous downstream processing

   Författare :Simon Tallvod; Avdelningen för kemiteknik; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Digital twins; Biopharmaceuticals; Downstream processing; Chromatography; Mathematical modeling; Ion exchange; Automation; Sampling; Model calibration; Python;

   Sammanfattning : Biopharmaceuticals are of ever-growing importance for human health. The development and production of biopharmaceuticals has the potential for efficiency improvements by switching from batch-wise to continuous production. LÄS MER

5. 4. Engineering Yeast for the Production of Biologicals

   Författare :Veronica Gast; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; biopharmaceuticals; genome-scale models.; kinase Gcn2; Recombinant protein production; proteases; Saccharomyces cerevisiae; biologicals;

   Sammanfattning : The market for biopharmaceutical proteins, or biologicals, has been expanding rapidly over the last decades and its value was estimated in 2020 to exceed 300 billion US dollars. Efficient cell factories that produce the biologicals fulfill an essential role within this industry. LÄS MER

7. 5. Advancing portable, aqueous drug delivery to the human lung

   Författare :Torben Last; Göran Stemme; Niclas Roxhed; Claus-Michael Lehr; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Portable Inhaler; Biopharmaceuticals; Soft-mist inhaler; Transport vesicles; Microfluidic packaging; High-pressure microfluidics; aerosolization; cleanroom-free fabrication; drug delivery; micro-electromechanical systems MEMS ; Applied Medical Technology; Tillämpad medicinsk teknik;

   Sammanfattning : Lung disease profoundly impacts human health: many lung diseases are currently without cure and require continued treatment. Due to their ease of use and integration into the daily routine, portable inhalers are the preferred treatment option for patients. LÄS MER