Sökning: "Snap Factor"

Visar resultat 6 - 9 av 9 avhandlingar innehållade orden Snap Factor.

  1. 6. Genetic code expansion in neurons for studying pathogenic mechanisms of Alzheimer disease

    Författare :Lea Susanne van Husen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Every three seconds a new patient is diagnosed with Alzheimer disease (AD). The primary risk factor for this irreversible, progressive brain disorder is old age. It is a growing health concern, not only for the patients, but also for their relatives and society, because the number of affected people is expected to double every 20 years. LÄS MER

  3. 7. Pathophysiological effects of alpha-synuclein on SNARE complex proteins in models of alpha-synucleinopathies

    Författare :Emma Brolin; Joakim Bergström; Anna Erlandsson; Martin Ingelsson; Arianna Bellucci; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha-synuclein; Parkinson’s disease; synaptosome; SNARE complex; proximity ligation assay; extracellular vesicles;

    Sammanfattning : Accumulation and spread of alpha-synuclein (α-syn) aggregates are central to the disease pathogenesis of Parkinson’s disease and dementia with Lewy bodies, collectively known as α-synucleinopathies. Native α-syn is a monomeric presynaptic protein that can act as a molecular chaperone for the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex assembly. LÄS MER

  4. 8. Perpendicular to grain fracture analysis of wooden structural elements - Models and applications

    Författare :Henrik Danielsson; Byggnadsmekanik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; fracture mechanics; cohesive zone modeling; Weibull theory; wood; glulam; orthotropy; heterogeneity; hole; dowel; asymmetric loading;

    Sammanfattning : This thesis concerns experimental and theoretical work regarding perpendicular to grain fracture in wooden structural elements. The experimental part concerns strength tests of glulam beams with a hole. LÄS MER

  5. 9. Energy metabolic failure within the arterial wall in atherosclerosis

    Författare :Max Levin; Göteborgs universitet; []
    Nyckelord :atherosclerosis; hypoxia; hypoxia marker; bioluminescence imaging; ATP; glucose; lactate; energy metabolism;

    Sammanfattning : Atherosclerosis is a disease that affects large and medium sized arteries. The majority of deaths in a Western population can be directly attributed to complications of this disease. Although research efforts have been vast, the pathophysiological mechanisms underlying atherosclerosis are not fully understood. LÄS MER