Sökning: "hypoxia marker"

Visar resultat 1 - 5 av 42 avhandlingar innehållade orden hypoxia marker.

  1. 1. Imaging the tumor microenvironment : the dynamics and modification of hypoxia

    Författare :Anna Ljungkvist; Peggy L. Olive; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiology; tumor microenvironment; double hypoxic marker method; proliferation; hypoxia; hypoxic half-life; Radiologisk forskning; Radiological research; Radiologisk forskning; diagnostisk radiologi; Diagnostic Radiology;

    Sammanfattning : The tumor vasculature is poor and heterogeneous which may result in inadequate oxygenation and changed energy status. In addition the balance between cell proliferation and the rate of cell death is disturbed, which results in tumor growth. LÄS MER

  3. 2. Energy metabolic failure within the arterial wall in atherosclerosis

    Författare :Max Levin; Göteborgs universitet; []
    Nyckelord :atherosclerosis; hypoxia; hypoxia marker; bioluminescence imaging; ATP; glucose; lactate; energy metabolism;

    Sammanfattning : Atherosclerosis is a disease that affects large and medium sized arteries. The majority of deaths in a Western population can be directly attributed to complications of this disease. Although research efforts have been vast, the pathophysiological mechanisms underlying atherosclerosis are not fully understood. LÄS MER

  4. 3. Prognostic and Treatment Predictive Markers Associated with Cyclin D1 Gene Amplification and Epithelial-Mesenchymal Transition in Breast Cancer

    Författare :Katja Lundgren; Malmö Patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; beta-arrestin1; Chk1; Breast Cancer; Tamoxifen; prognostic marker; predictive marker; gene amplification; cyclin D1; EMT; Snail; hypoxia;

    Sammanfattning : Endocrine resistant breast cancer is a major therapeutical challenge and accurate selection of patients susceptible to certain types of anti-hormonal treatment strategies is pivotal. Discovery of novel biomarkers potentially predicting treatment response as well as the clinical course of breast cancer is essential to effectively improve therapies and diagnosis. LÄS MER

  5. 4. Hypoxia and differentiation in human neuroblastoma cells

    Författare :Helén Nilsson; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ontogeny; embryology human ; Utvecklingsbiologi; teratologi; embryologi människa ; teratology; cytogenetik; Development biology; cytogenetics; Genetik; Genetics; Medicin människa och djur ; HIF; Medicine human and vertebrates ; MYCN; Hypoxia; differentiation; Neuroblastoma;

    Sammanfattning : The childhood tumour neuroblastoma is derived from immature cells of the sympathetic nervous system, which have become arrested at different maturation stages. Neuroblastoma is a malignancy with a high degree of heterogeneity, and there is a correlation between a poor differentiation status and a more aggressive phenotype. LÄS MER

  7. 5. Hypoxia-induced phenotypic modulation of human neuroblastoma cells

    Författare :Linda Holmquist Mengelbier; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; reoxygenation; HIF-2a; HIF-1a; differentiation; hypoxia; neuroblastoma;

    Sammanfattning : Neuroblastoma is a childhood tumour derived from cells of the sympathetic nervous system, which are arrested at low differentiation stages. Low differentiation stage and high tumour stage correlate to poor outcome. LÄS MER