Sökning: "Signal transduction"

Visar resultat 21 - 25 av 387 avhandlingar innehållade orden Signal transduction.

  1. 21. Adaptive Responses by Transcriptional Regulators to small molecules in Prokaryotes : Structural studies of two bacterial one-component signal transduction systems DntR and HpNikR

    Författare :Cyril Dian; Peter Brzezinski; Séan McSweeney; Elisabeth Sauer-Eriksson; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transcription regulator; bacterial biosensor; LysR family; Inducer-binding; nickel-sensing; NikR; signal transduction system; Helicobacter pylori; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Prokaryotes are continually exposed to variations in their environment. Survival in unstable milieu requires a wide range of transcriptional regulators (TRs) that respond to specific environmental and cellular signals by modulating gene expression and provide an appropriate physiological response to external stimuli. LÄS MER

  3. 22. Platelet-derived growth factor-induced signal transduction

    Författare :Sigrídur Valgeirsdóttir; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cellbiologi; Cell biology; Cellbiologi; molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Platelet-derived growth factor (PDGF), a potent mitogen for mesenchymal cells, elicits its effects by binding to cell surface tyrosine kinase receptors, denoted α- and β-receptors. This thesis describes the mechanism of interaction between stimulated PDGF receptors and various intracellular molecules. LÄS MER

  4. 23. Alpha-2 Adrenergic Receptors and Signal Transduction : Effector Output in Relation to G-Protein Coupling and Signalling Cross-Talk

    Författare :Johnny Näsman; Peter Evans; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; Adrenergic; receptor; G-protein; adenylyl cyclase; cAMP; calcium; cross-talk; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

    Sammanfattning : The alpha-2 adrenergic receptor (α2-AR) subfamily includes three different subtypes, α2A-, α2B- and α2C-AR, all believed to exert their function through heterotrimeric Gi/o-proteins. The present study was undertaken in order to investigate subtype differences in terms of cellular response and to explore other potential signalling pathways of α2-ARs. LÄS MER

  5. 24. Dopamine D2 and D3 receptors. Studies on transduction mechanisms and on the role of a D3 gene polymorphism

    Författare :Monika Hellstrand; Göteborgs universitet; []
    Nyckelord :dopamine; dopamine D2 receptor; dopamine D3 receptor; transduction; CHO cells; partial agonism; inverse agonism; arachidonic acid; prostaglandin E2; cAMP; haloperidol; -3-PPP; PNU-99194A; polymorphism; personality;

    Sammanfattning : The neurotransmitter dopamine has been implicated in the pathophysiology of, e.g., Parkinson s disease and schizophrenia, and dopamine receptor-active compounds are commonly employed therapeutically in these and other disorders. LÄS MER

  7. 25. Signal Transduction by Proline-Rich Tyrosine Kinase Pyk2

    Författare :Inga Dikic; Olli Silvennoinen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi; Protein phosphorylation; tyrosine kinase; Pyk2 FAK; neuronal differentiation; Ras MAP kinase pathway; Oncology; Onkologi; molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : The proline-rich tyrosine kinase (Pyk2) together with focal adhesion kinase (FAK) define a family of non-receptor protein tyrosine kinases that are regulated by diverse stimuli. Activation of Pyk2 has been implicated in multiple signaling events, including modulation of ion channels, activation of MAP kinase cascades and apoptotic cell death. LÄS MER