Sökning: "Shotgun proteomics"

Visar resultat 6 - 10 av 24 avhandlingar innehållade orden Shotgun proteomics.

  1. 6. Parameterized algorithms for hitting set variants applied to protein identification in shotgun proteomics

    Författare :Leonid Molokov; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Union Editing; Fixed Parameter Tractable; Shotgun proteomics; Hitting Set; Parameterized complexity; Hypergraph; Set Cover;

    Sammanfattning : This work is dedicated to problem of protein identification in bottom-up proteomics, and in particular, in shotgun proteomics. It is aimed on providing a new way of interpretation of peak lists. LÄS MER

  3. 7. Quality Control for high-throughput Quantitative Proteomics - Harnessing the potential of label-free LC-MS

    Författare :Marianne Sandin; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; mass spectrometry; quality control; data analysis; label-free; feature detection; alignment; biomarker discovery; separation techniques;

    Sammanfattning : Multiplex protein quantification, proteomics, is essential for uncovering new biomarkers and understanding biology. Liquid chromatography coupled to mass spectrometry (LC-MS) is the predominant technique for these measurements. LÄS MER

  4. 8. Profiling the cancer proteome

    Författare :Sofia Waldemarson; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytologi; onkologi; cancer; Biotechnology; Bioteknik; cancerology; oncology; Cytology; iTRAQ; biomarkers; DIGE; two-dimensional gel electrophoresis; Proteomics;

    Sammanfattning : Cancer is a complex and heterogeneous disease where cells have started to grow uncontrolled and this disease remains a major health problem. Because of diffuse symptoms it often presents at a late stage. LÄS MER

  5. 9. Protein Mixture Inference as Hitting Set Variants and Linear Algebra Problems

    Författare :Leonid Molokov; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Union Editing; Shotgun proteomics; Parameterized complexity; Protein Inference; Shared Peptides; Set Cover; Hypergraph; Hitting Set; Fixed Parameter Tractable; Protein Quan- ti; Star Editing;

    Sammanfattning : This work is dedicated to the problems of protein inference and quantification in bottom-up proteomics, and, in particular, in shotgun proteomics. We adopt a rather classical approach of representing inference problem as a set cover, where proteins are understood as sets of their observations: peptides' masses or sequences. LÄS MER

  7. 10. A Proteomic Dissection of Breast Cancer - Via Cells and Organelles to Pathways

    Författare :Linn Antberg; Institutionen för immunteknologi; []
    Nyckelord :Proteomics; Mass spectrometry; Breast cancer; DNA repair; Organelle fractionation; Tumour subpopulations;

    Sammanfattning : Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in females worldwide. Breast tumours are extremely heterogeneous, and each patient’s disease has different causes, prognosis and appropriate treatments associated with it. LÄS MER