Sökning: "Shotgun proteomics"

Visar resultat 16 - 20 av 24 avhandlingar innehållade orden Shotgun proteomics.

  1. 16. Chromatographic retention time prediction and its applications in mass spectrometry-based proteomics

    Författare :Luminita Moruz; Lukas Käll; Arne Elofsson; Benno Schwikowski; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry; reversed-phase liquid chromatography; retention time prediction; bioinfomatics; computational mass spectrometry; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Sammanfattning : Mass spectrometry-based methods are among the most commonly used techniques to characterize proteins in biological samples. With rapid technological developments allowing increasing throughput, thousands of proteins can now be monitored in a matter of hours. However, these advances brought a whole new set of analytical challenges. LÄS MER

  3. 17. Multivariate analysis of cancer proteomics data : towards a biological systems view and understanding

    Författare :Lina Hultin Rosenberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Important aims of cancer proteomics include gaining better understanding of cancer biology and identifying cancer biomarkers. Mass spectrometry (MS) based shotgun proteomics allow for identification and quantification of thousands of proteins in complex human samples. LÄS MER

  4. 18. Advancing bioinformatics methods for in-depth proteome analysis based on high-resolution mass spectrometry

    Författare :Bo Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mass spectrometry-based shotgun proteomics has become one of the essential techniques for comprehensive studies of living systems. Due to the inherent complexity of proteomes and the data, bioinformatics plays a critical role to translate mass spectra into biological information and knowledge. LÄS MER

  5. 19. A model for membrane organization and protein sorting in the cyanobacterium Synechocystis sp. PCC 6803

    Författare :Tatiana Pisareva; Birgitta Norling; Colin Robinson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; Biochemistry; biokemi;

    Sammanfattning : Cyanobacteria constitute a unique group of eubacteria, possessing outer and plasma membranes as well as internal thylakoid membranes, the site for both photosynthesis and respiration. The combination of sucrose density centrifugation and two-phase partitioning methods leads to purification of different membranes from the cyanobacterium Synechocystis sp. LÄS MER

  7. 20. Quantitative proteomic approaches for the analysis of human lung samples in pulmonary sarcoidosis

    Författare :Ernesto Silva; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis is focused on the analysis of protein expression profiles from the airways of sarcoidosis patients using quantitative proteomics. Sarcoidosis is a multisystemic inflammatory disorder of unknown etiology characterized by the presence of noncaseating granulomas in the affected organs. LÄS MER