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Visar resultat 1 - 5 av 29 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Use and misuse of sedative drugs and related substances - Findings in the general population and in individuals with opioid dependence

   Författare :Tove Abrahamsson; Lund Psykiatri; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Substance use; Sedatives; Anxiolytics; Hypnotics; Prescription drug miuse; Benzodiazepines; Z-drugs; Pregabalin; Self-assessed health; Quality of life; Opioid dependence; Opiate maintenance treatment; Mortality;

   Sammanfattning : Background: Prescription sedatives are efficient in the treatment of anxiety and sleeping disorders, but are associated with a risk of misuse and dependence, as well as an increased risk of accidents, injuries and overdoses, both in the general population and especially in individuals with other substance misuse. The present thesis aims to investigate prescription sedative use and misuse in two kinds of samples - in the general population, with focus on its association with subjective health and quality life, and in the subpopulation of individuals with opioid dependence, with focus on treatment outcome in opioid maintenance treatment and mortality. LÄS MER

3. 2. Spotting pain in the brain. Towards a useful animal model of pain

   Författare :Tanja Jensen; Neurofysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; analgesics; freely moving rat; microelectrode; Nociception; Primary somatosensory cortex; Sedatives;

   Sammanfattning : Current models of pain in conscious animals usually scores nocifensive responses. However, it is still unclear to what extent these responses are related to, for instance, the sensory discriminative or affective aspects of pain. LÄS MER

4. 3. Trauma - logistics and stress response

   Författare :Camilla Brorsson; Silvana Naredi; Anders Sylvan; Per Dahlqvist; Mikael Bodelsson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; traumatic brain injury; multiple trauma; hydrocortisone; adrenal insufficiency; hypnotics and sedatives; citric acid; glycerol; saliva; liver; colorectal surgery;

   Sammanfattning : Background: Trauma is a major cause of death and disability. Adverse events, such as prolonged prehospital time, hypoxia, hypotension and/or hyperventilation have been reported to correlate to poor outcome.Adequate cortisol levels are essential for survival after major trauma. LÄS MER

5. 4. The rational use of drugs in a population of very old persons

   Författare :Maria Stella T Giron; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : This thesis investigated the use of drugs in a population of very old persons. The pattems of use, particularly of psychotropic drugs, and its appropriateness were assessed. Drug use was also assessed according to dementia diagnosis and in relation to the presence of psychiatric illnesses. LÄS MER

7. 5. Drug use in the elderly : risk or protection? Findings from the Kungsholmen project

   Författare :Christel Cornelius; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Drug use; elderly; dementia; Alzheimer s disease; aspirin; NSAIDs; glucocorticoids; calcium channel blockers; apolipoprotein E; population-based study.;

   Sammanfattning : This thesis deals with different aspects of drug use in a population-based study with participants 75 years and older. The study was performed within the Kungsholmen Project in Stockholm, Sweden, using data from the baseline survey (1987-89), and the first (1991-93) and second (1994-96) followups In the first two papers we used cross-sectional data (n=1810) to describe tile drug Ilse pattern ill this population (I), and to examine the association between self-reported symptoms and drug use (II). LÄS MER