Sökning: "Scavenger receptor"

Visar resultat 6 - 10 av 48 avhandlingar innehållade orden Scavenger receptor.

1. 6. Studies on scavenger receptor class B type I and genes implicated in foam cell formation

   Författare :Per-Arne Svensson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; scavenger receptor class B type I; high-density lipoprotein; oxidized low-density lipoprotein; macrophages; expression profiling;

   Sammanfattning : The risk of atherosclerosis correlates with plasma levels of low-density lipoprotein (LDL) cholesterol and is inversely correlated to plasma levels of high-density lipoprotein (HDL) cholesterol. Accumulation of oxidized LDL (oxLDL) by arterial macrophages is a key event in the development of atherosclerosis. LÄS MER

3. 7. CXCL16 and CD137 in atherosclerosis

   Författare :Dick Wågsäter; Allan Sirsjö; Ewa Ehrenborg; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; atherosclerosis; chemokine; cytokine; endothelial cells; inflammation; low-density lipoprotein; macrophages; scavenger receptor; smooth muscle cells; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; MEDICINE; MEDICIN; Biomedicin; Biomedicine;

   Sammanfattning : Atherosclerosis is a progressive inflammatory disease that is characterized by the accumulation of lipids, infiltrated cells and fibrous elements in large arteries. This thesis focuses on the molecular mechanisms behind foam cell formation and inflammation, two central processes in the development of atherosclerosis. LÄS MER

4. 8. Developmental role and ligand binding properties of macrophage scavenger receptor MARCO

   Författare :Yunying Chen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Macrophages express several cell surface receptors, that mediate the recognition of a wide range of endogenous and exogenous ligands. In this manner, macrophages are able to perform their multiple biological functions in regulation of homeostasis and host defense. LÄS MER

5. 9. Megalin, an Endocytotic Receptor with Signalling Potential

   Författare :Mårten Larsson; Lars Rask; Bo Åkerström; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Megalin; LRP-2; Postsynaptic density-95; Retinol-binding protein; Oligodendrocytes; Central nervous system; Biokemi; Biochemistry; Biokemi;

   Sammanfattning : Megalin is an endocytotic receptor belonging to the low-density lipoprotein family. It has often been viewed only as merely a scavenger receptor of absorptive and secretory epithelia. Recent work has revealed that the megalin intracellular domain contains several motifs potentially binding proteins involved in signal transduction. LÄS MER

7. 10. Hyaluronan receptors of liver endothelial cells, their purification and characterisation

   Författare :Peter A. G. McCourt; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; hyaluronan; scavenger receptors; ICAM-1; liver endothelial cells; Biokemi; Biochemistry; Biokemi; fysiologi; Physiology;

   Sammanfattning : Hyaluronan (HA) is a polysaccharide common throughout the connective tissues. and is found at low concentrations in the blood. The major site of its clearance is via an endocytic receptor on liver endothelial cells (LEC). This process is vital, as excessive serum levels of HA lead to clotting disorders and overly viscous blood. LÄS MER