Sökning: "Scavenger receptor"

Visar resultat 16 - 20 av 48 avhandlingar innehållade orden Scavenger receptor.

1. 16. Design and synthesis of steroid mimetic libraries using solid phase techniques

   Författare :Marcus Ruda; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Pyridone; quinolone; benzoindazole; solid phase chemistry; scavenger resin; combinatorial chemistry; alpha-arylation; nuclear hormone receptor; steroid mimetic.;

   Sammanfattning : This thesis deals with the design and synthesis of biologically active ligands for nuclear hormone receptors using combinatorial techniques. In the first part, a 5,6,6a,7,8,9,10,10a-octahydrobenzo[f]quinolin-3(4H)-one tricyclic core structure was designed mimicking the ABC-rings of a steroid. LÄS MER

3. 17. Cellular immunity and inflammation in atherosclerosis

   Författare :Dirk Marcus Wuttge; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Atherosclerosis; T cell; oxLDL; malondialdehyde; hapten; posttranslational; interleukin-] 5; retinoic acid receptor; inflammation;

   Sammanfattning : Atherosclerosis, the major cause of death and disability in western countries, is nowadays recognized as an inflammatory disease. Low density lipoprotein (LDL), the major carrier of cholesterol in plasma, is trapped in the subendothelial space, where compounds inside of LDL are chemically modified through lipid peroxidation. LÄS MER

4. 18. Cell-penetrating peptides : an uptake mechanism & a new endosomolytic peptide

   Författare :Henrik Helmfors; Ülo Langel; Andreas Barth; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell-penetrating peptides; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Peptide-based drugs have slowly begun migrating from laboratories into pharmacies and now there are several on the market. However, currently only one gene based therapy that is relies on a viral delivery vector has been approved. LÄS MER

5. 19. Peptide-based delivery to glioblastoma cells studied by the blood-brain barrier model

   Författare :Artita Srimanee; Ülo Langel; Ing-Marie Nilsson; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; peptide-based delivery; blood-brain barrier; glioblastoma; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Crossing the blood-brain barrier (BBB) is a great challenge for delivery of highly charged macromolecules such as nucleic acids and proteins to the brain. Cell-penetrating peptides (CPPs) are promising vectors to deliver various cargoes ranging from small molecules to large molecules such as antibodies, proteins, and nucleic acids. LÄS MER

7. 20. Development of probes for molecular imaging : evaluation in models of inflammation and atherosclerosis

   Författare :Mona Ahmed; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The imaging field is rapidly evolving and in the last two decades there have been tremendous developments in the field of multimodal imaging. Multimodal molecular imaging approaches that utilize ultrasound/magnetic resonance imaging (US/MRI), single-photon emission computed tomography/computed tomography (SPECT/CT), or positron emission tomography/MRI (PET/MRI) may provide additional detailed information at the cellular and molecular level to help identify patients with vulnerable plaques that are at risk of rupture. LÄS MER