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Hittade 4 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Reversible Sulfur Reactions in Pre-Equilibrated and Catalytic Self-Screening Dynamic Combinatorial Chemistry Protocols

    Författare :Rikard Larsson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Dynamic Combinatorial Chemistry; Reversible sulfur reactions; Catalytic self-screening; Carbohydrates; Lectins; Quartz Crystal Microbalance; Organic chemistry; Organisk kemi;

    Sammanfattning : Dynamic Combinatorial Chemistry (DCC) is a recently introduced supramolecular approach to generate dynamically interchanging libraries of compounds. These libraries are made of different building blocks that reversibly interact with one another and spontaneously assemble to encompass all possible combinations. LÄS MER

  3. 2. Dynamic Sulfur Chemistry : Screening, Evaluation and Catalysis

    Författare :Rémi Caraballo; Olof Ramström; Nicolas Giuseppone; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Dynamic combinatorial chemistry; dynamic sulfur chemistry; thioglycoside; mutarotation; disulfide metathesis; hemithioacetal formation; 1H STD-NMR; inhibition; phosphine; Concanavalin A; beta-galactosidase; dynamic drug discovery.; Chemistry; Kemi; Organic chemistry; Organisk kemi; Bioorganic chemistry; Bioorganisk kemi;

    Sammanfattning : This thesis deals with the design, formation and evaluation of dynamic systems constructed by means of sulfur-containing reversible reactions, in organic and aqueous media and under mild conditions. In a first part, the synthesis of thioglycoside derivatives, constituting the biologically relevant starting components of the dynamic systems, is described. LÄS MER

  4. 3. C–H activation through late transition metal cyclometallation. Addressing selectivity and reactivity problems

    Författare :Mikhail Kondrashov; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; C—H activation; cyclometallation; pincer ligands; anion exchange; bimetallic complexes; oxidative functionalisation;

    Sammanfattning : The ligand-directed C—H activation relies on a coordinating donor atom being in proximity to the C—H bond activated. Cyclometallation of 2-(1-naphthyl)-pyridine – a substrate containing both γ- and δ-positions in proximity to the directing nitrogen atom – was studied. LÄS MER

  5. 4. Characterization of thioredoxin related protein of 14 kDa and its role in redox signaling

    Författare :Irina Pader; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Reversible reduction/oxidation (redox) reactions play key roles in cellular signaling pathways. Particularly cysteine residues in proteins can be modified by reactive oxygen-, nitrogen- or sulfur species (ROS, RNS, RSS), thereby altering the functions of the respective proteins. LÄS MER